Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis.
about
Yap1 acts downstream of α-catenin to control epidermal proliferationOverexpression of DPAGT1 leads to aberrant N-glycosylation of E-cadherin and cellular discohesion in oral cancerα-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structuresRapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryosRegulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions.αE-catenin actin-binding domain alters actin filament conformation and regulates binding of nucleation and disassembly factorsThe catenin family at a glance.AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion.Telomerase variant A279T induces telomere dysfunction and inhibits non-canonical telomerase activity in esophageal carcinomas.α(E)-catenin regulates BMP-7 expression and migration in renal epithelial cellsThe evolutionary origin of epithelial cell-cell adhesion mechanismsα-catenin. A tumor suppressor beyond adherens junctions.A role for the age-dependent loss of α(E)-catenin in regulation of N-cadherin expression and cell migrationDifferential proteomics identifies PDIA3 as a novel chemoprevention target in human colon cancer cells.Wnt signaling in estrogen-induced lactotroph proliferation.Loss of α(E)-catenin potentiates cisplatin-induced nephrotoxicity via increasing apoptosis in renal tubular epithelial cellsN-cadherin-mediated cell adhesion restricts cell proliferation in the dorsal neural tube.The R(h)oads to Stat3: Stat3 activation by the Rho GTPases.Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy.A conserved phosphorylation switch controls the interaction between cadherin and β-catenin in vitro and in vivo.Circulating mRNA Profiling in Esophageal Squamous Cell Carcinoma Identifies FAM84B As A Biomarker In Predicting Pathological Response to Neoadjuvant ChemoradiationαE-catenin regulates cell-cell adhesion and membrane blebbing during zebrafish epiboly.Loss of α(E)-catenin promotes Fas mediated apoptosis in tubular epithelial cells.The secret life of α-catenin: moonlighting in morphogenesis.A non-tight junction function of claudin-7-Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment.α-Catenin inhibits β-catenin-T-cell factor/lymphoid enhancing factor transcriptional activity and collagen type II expression in articular chondrocytes through formation of Gli3R.α-catenin.β-catenin ternary complex.α-Catulin marks the invasion front of squamous cell carcinoma and is important for tumor cell metastasis.Specific conserved C-terminal amino acids of Caenorhabditis elegans HMP-1/α-catenin modulate F-actin binding independently of vinculin.αE-catenin inhibits a Src-YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway.Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer.Alpha-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular trafficEvolution and cell physiology. 3. Using Dictyostelium discoideum to investigate mechanisms of epithelial polarity.EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.Lipopolysaccharide-induced α-catenin downregulation enhances the motility of human colorectal cancer cells in an NF-κB signaling-dependent manner.Beyond structure, to survival: activation of Stat3 by cadherin engagement.Spatial regulation of receptor tyrosine kinases in development and cancer.Structural and functional characterization of the α-catenin·β-catenin binding interface in Caenorhabditis elegans reveals conserved requirements for cell-cell adhesion in metazoans.α-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of β-catenin transactivation.Plakoglobin interacts with and increases the protein levels of metastasis suppressor Nm23-H2 and regulates the expression of Nm23-H1.
P2860
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P2860
Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Bench to bedside and back agai ...... on and roles in tumorigenesis.
@en
type
label
Bench to bedside and back agai ...... on and roles in tumorigenesis.
@en
prefLabel
Bench to bedside and back agai ...... on and roles in tumorigenesis.
@en
P2860
P1476
Bench to bedside and back agai ...... on and roles in tumorigenesis.
@en
P2093
Jacqueline M Benjamin
W James Nelson
P2860
P356
10.1016/J.SEMCANCER.2007.08.003
P577
2007-09-04T00:00:00Z