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Constitutively active ALK2 receptor mutants require type II receptor cooperation

Constitutively active ALK2 receptor mutants require type II receptor cooperation

http://www.wikidata.org/entity/Q36978228

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TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation Activin receptor-like kinases: a diverse family playing an important role in cancer The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants.Bone Morphogenetic Protein (BMP) signaling in development and human diseases Adult-specific systemic over-expression reveals novel in vivo effects of the soluble forms of ActRIIA, ActRIIB and BMPRII.Molecular and cellular mechanisms of heterotopic ossification.Apyrase as a novel therapeutic inhibitor of heterotopic ossification Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma.Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders.Granting immunity to FOP and catching heterotopic ossification in the Act.Recent advances in understanding contextual TGFβ signaling Signaling Receptors for TGF-β Family Members.Mutant activin-like kinase 2 in fibrodysplasia ossificans progressiva are activated via T203 by BMP type II receptors Conserved signaling pathways underlying heterotopic ossification.Application of human induced pluripotent stem cells to model fibrodysplasia ossificans progressiva.Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans Progressiva.BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development.Regulation of continuous but complex expression pattern of Six1 during early sensory development.Variable signaling activity by FOP ACVR1 mutations.Animal models of fibrodysplasia ossificans progressiva.Variant BMP receptor mutations causing fibrodysplasia ossificans progressiva (FOP) in humans show BMP ligand-independent receptor activation in zebrafish.Stem cells and heterotopic ossification: Lessons from animal models.The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development.ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.

P2860

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P2860

Constitutively active ALK2 receptor mutants require type II receptor cooperation

http://www.wikidata.org/entity/Q36978228

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

Constitutively active ALK2 receptor mutants require type II receptor cooperation

@en

type

label

Constitutively active ALK2 receptor mutants require type II receptor cooperation

@en

prefLabel

Constitutively active ALK2 receptor mutants require type II receptor cooperation

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Molecular and Cellular Biology

P1476

Constitutively active ALK2 receptor mutants require type II receptor cooperation

@en

P2093

Alex N Bullock

http://www.w3.org/2001/XMLSchema#string

Ashley J Vonner

http://www.w3.org/2001/XMLSchema#string

Carol S C Lai

http://www.w3.org/2001/XMLSchema#string

Donna Y Deng

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Hideyuki Beppu

http://www.w3.org/2001/XMLSchema#string

Ivan Alfano

http://www.w3.org/2001/XMLSchema#string

Jan Börgermann

http://www.w3.org/2001/XMLSchema#string

Jana Bagarova

http://www.w3.org/2001/XMLSchema#string

Kelli A Armstrong

http://www.w3.org/2001/XMLSchema#string

Petra Knaus

http://www.w3.org/2001/XMLSchema#string

P2860

Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension

A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors

BMP type I receptor inhibition reduces heterotopic [corrected] ossification

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva

Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2

BMP signaling is required for septation of the outflow tract of the mammalian heart

The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

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2413-2424

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scholarly article

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10.1128/MCB.01595-12

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12

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33

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Panagis Filippakopoulos

Nicholas W Morrell

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2013-04-09T00:00:00Z

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236189140

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23572558

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3700091

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