Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels.
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SAMHD1 has differential impact on the efficacies of HIV nucleoside reverse transcriptase inhibitors.SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitorsA continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1Substrates and Inhibitors of SAMHD1.Select host restriction factors are associated with HIV persistence during antiretroviral therapy.Differential regulatory activities of viral protein X for anti-viral efficacy of nucleos(t)ide reverse transcriptase inhibitors in monocyte-derived macrophages and activated CD4(+) T cellsDual anti-HIV mechanism of clofarabineHeterozygous colon cancer-associated mutations of SAMHD1 have functional significanceGTP is the primary activator of the anti-HIV restriction factor SAMHD1.The feasibility of incorporating Vpx into lentiviral gene therapy vectors.Deoxyribonucleotides as genetic and metabolic regulatorsThe druggability of intracellular nucleotide-degrading enzymes.Novel inhibitors of human immunodeficiency virus type 2 infectivity.SAMHD1 is a barrier to antimetabolite-based cancer therapies.Fidelity of classwide-resistant HIV-2 reverse transcriptase and differential contribution of K65R to the accuracy of HIV-1 and HIV-2 reverse transcriptases.SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells.HIV-2 infects resting CD4+ T cells but not monocyte-derived dendritic cells.SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.
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P2860
Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 June 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Anti-HIV host factor SAMHD1 re ...... de triphosphate (dNTP) levels.
@en
Anti-HIV host factor SAMHD1 re ...... oxyribonucleoside triphosphate
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type
label
Anti-HIV host factor SAMHD1 re ...... de triphosphate (dNTP) levels.
@en
Anti-HIV host factor SAMHD1 re ...... oxyribonucleoside triphosphate
@nl
prefLabel
Anti-HIV host factor SAMHD1 re ...... de triphosphate (dNTP) levels.
@en
Anti-HIV host factor SAMHD1 re ...... oxyribonucleoside triphosphate
@nl
P2093
P2860
P356
P1476
Anti-HIV host factor SAMHD1 re ...... de triphosphate (dNTP) levels.
@en
P2093
Erin Noble
Michele B Daly
Robert A Bambara
Sarah M Amie
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P304
20683-20691
P356
10.1074/JBC.M113.472159
P407
P577
2013-06-05T00:00:00Z