Mapping the subcellular distribution of α-synuclein in neurons using genetically encoded probes for correlated light and electron microscopy: implications for Parkinson's disease pathogenesis
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Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Photooxidation-guided ultrastructural identification and analysis of cells in neuronal tissue labeled with green fluorescent proteinNeuroimaging of Parkinson's disease: Expanding views.Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption.Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR.Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicityFormation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.Pannexin2 oligomers localize in the membranes of endosomal vesicles in mammalian cells while Pannexin1 channels traffic to the plasma membraneMetallothionein as a clonable tag for protein localization by electron microscopy of cells.Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease.Genetically targeted 3D visualisation of Drosophila neurons under Electron Microscopy and X-Ray Microscopy using miniSOG.Cholesterol in the Pathogenesis of Alzheimer's, Parkinson's Diseases and Autism: Link to Synaptic DysfunctionConformational heterogeneity of α-synuclein in membrane.Correlative fluorescence and electron microscopyA workflow for the automatic segmentation of organelles in electron microscopy image stacks.Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation.Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity.O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's diseaseAggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to LysosomesVisualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy.Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain.Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative diseaseG2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.The function of α-synuclein.Parallel mechanisms for direct and indirect membrane protein trafficking by synucleins.Pharmacological chaperoning of nAChRs: a therapeutic target for Parkinson's disease.Genetics and genomics of Parkinson's disease.Models of α-synuclein aggregation in Parkinson's disease.The prion hypothesis of Parkinson's disease.Proteomic analysis of Nipponia nippon (ID#162).Endothelin-converting enzymes degrade α-synuclein and are reduced in dementia with Lewy bodies.Live correlative light-electron microscopy to observe molecular dynamics in high resolution.Applications of genetically encoded photosensitizer miniSOG: from correlative light electron microscopy to immunophotosensitizing.Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology.Self-labelling enzymes as universal tags for fluorescence microscopy, super-resolution microscopy and electron microscopy.Synucleins Have Multiple Effects on Presynaptic Architecture.Current concepts and controversies in the pathogenesis of Parkinson's disease dementia and Dementia with Lewy Bodies.The number of α-synuclein proteins per vesicle gives insights into its physiological function.FLIPPER, a combinatorial probe for correlated live imaging and electron microscopy, allows identification and quantitative analysis of various cells and organelles.
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Mapping the subcellular distribution of α-synuclein in neurons using genetically encoded probes for correlated light and electron microscopy: implications for Parkinson's disease pathogenesis
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on February 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Mapping the subcellular distri ...... rkinson's disease pathogenesis
@en
Mapping the subcellular distri ...... kinson's disease pathogenesis.
@nl
type
label
Mapping the subcellular distri ...... rkinson's disease pathogenesis
@en
Mapping the subcellular distri ...... kinson's disease pathogenesis.
@nl
prefLabel
Mapping the subcellular distri ...... rkinson's disease pathogenesis
@en
Mapping the subcellular distri ...... kinson's disease pathogenesis.
@nl
P2093
P2860
P921
P1476
Mapping the subcellular distri ...... rkinson's disease pathogenesis
@en
P2093
Daniela Boassa
Eric A Bushong
Julia M George
Mark H Ellisman
Mary Ann Yang
Masako Terada
Minju Hwang
Monica L Berlanga
P2860
P304
P356
10.1523/JNEUROSCI.2898-12.2013
P407
P577
2013-02-01T00:00:00Z