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Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemiaTargeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.Force-induced unfolding simulations of the human Notch1 negative regulatory region: possible roles of the heterodimerization domain in mechanosensingStructure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALLEffects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2Thermodynamic and structural insights into CSL-DNA complexesAlterations of the Notch pathway in lung cancer.Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation.Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in miceGamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrinPancreatic cancer.Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.Absence of Association between CCR5 rs333 Polymorphism and Childhood Acute Lymphoblastic Leukemia.Angiocrine factors deployed by tumor vascular niche induce B cell lymphoma invasiveness and chemoresistanceMurine models of acute leukemia: important tools in current pediatric leukemia research.Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemiaAcute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specificationMutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.The HLH protein Extramacrochaetae is required for R7 cell and cone cell fates in the Drosophila eye.Transient responses to NOTCH and TLX1/HOX11 inhibition in T-cell acute lymphoblastic leukemia/lymphomaHIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in miceTLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells.Notch dimerization is required for leukemogenesis and T-cell development.T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell.Notch inhibitors for cancer treatment.Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.Dissecting and circumventing the requirement for RAM in CSL-dependent Notch signaling.Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance.Epigenetic inactivation of Notch-Hes pathway in human B-cell acute lymphoblastic leukemia.SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cellsEpidermal Notch signalling: differentiation, cancer and adhesion.Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways.A multicenter phase 1 study of γ -secretase inhibitor RO4929097 in combination with capecitabine in refractory solid tumors.Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cellsA SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Notch signaling in leukemia.
@en
Notch signaling in leukemia.
@nl
type
label
Notch signaling in leukemia.
@en
Notch signaling in leukemia.
@nl
prefLabel
Notch signaling in leukemia.
@en
Notch signaling in leukemia.
@nl
P2093
P2860
P1476
Notch signaling in leukemia.
@en
P2093
Jon C Aster
Stephen C Blacklow
Warren S Pear
P2860
P304
P356
10.1146/ANNUREV.PATHMECHDIS.3.121806.154300
P577
2008-01-01T00:00:00Z