The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity. - Test2 - elhamkhani - TriplyDB

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

http://www.wikidata.org/entity/Q37021087

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How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly Recent advances in understanding hepatic drug transport The metabolome 18 years on: a concept comes of age Hunting Viral Receptors Using Haploid Cells Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death MetMaxStruct: A Tversky-Similarity-Based Strategy for Analysing the (Sub)Structural Similarities of Drugs and Endogenous Metabolites Correlating chemical sensitivity and basal gene expression reveals mechanism of action.YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway Functional genomic screening approaches in mechanistic toxicology and potential future applications of CRISPR-Cas9.The over-expression of survivin enhances the chemotherapeutic efficacy of YM155 in human hepatocellular carcinoma.YM155 potently triggers cell death in breast cancer cells through an autophagy-NF-kB network Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells.Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer YM155, a survivin suppressant, triggers PARP-dependent cell death (parthanatos) and inhibits esophageal squamous-cell carcinoma xenografts in mice Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine.A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model.A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor.Drug screening and grouping by sensitivity with a panel of primary cultured cancer spheroids derived from endometrial cancer Vector Integration Sites Identification for Gene-Trap Screening in Mammalian Haploid Cells.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.Monitoring Cell-surface N-Glycoproteome Dynamics by Quantitative Proteomics Reveals Mechanistic Insights into Macrophage Differentiation.Effects of YM155 on survivin levels and viability in neuroblastoma cells with acquired drug resistance.Reactive Oxygen Species Synergize To Potently and Selectively Induce Cancer Cell Death.Role of Passive Diffusion, Transporters, and Membrane Trafficking-Mediated Processes in Cellular Drug Transport.Technical approaches to induce selective cell death of pluripotent stem cells.Harnessing Solute Carrier Transporters for Precision Oncology.The apparent permeabilities of Caco-2 cells to marketed drugs: magnitude, and independence from both biophysical properties and endogenite similarities.Analysis of drug-endogenous human metabolite similarities in terms of their maximum common substructures.Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine.Exploiting AR-Regulated Drug Transport to Induce Sensitivity to the Survivin Inhibitor YM155.Arrayed mutant haploid embryonic stem cell libraries facilitate phenotype-driven genetic screens.Solute carrier family 35 member F2 is indispensable for papillary thyroid carcinoma progression through activation of transforming growth factor-β type I receptor/apoptosis signal-regulating kinase 1/mitogen-activated protein kinase signaling axis.Recent advances in nanomedicine and survivin targeting in brain cancers.2016 EMBO Chemical Biology Conference.YM155 inhibits topoisomerase function.GeneGini: Assessment via the Gini Coefficient of Reference "Housekeeping" Genes and Diverse Human Transporter Expression Profiles.High doses of alcohol during pregnancy cause DNA damages in osteoblasts of newborns rats.

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The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

http://www.wikidata.org/entity/Q37021087

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 27 July 2014

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

@en

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

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type

label

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

@en

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

@nl

prefLabel

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

@en

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

@nl

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Nature Chemical Biology

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The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.

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Claudia Trefzer

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Doris Chen

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Georg E Winter

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Kilian V M Huber

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Manuela Gridling

http://www.w3.org/2001/XMLSchema#string

Richard K Kandasamy

http://www.w3.org/2001/XMLSchema#string

Thijn R Brummelkamp

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Thorsten Klampfl

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Vincent A Blomen

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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast

Haploid genetic screens in human cells identify host factors used by pathogens

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

RNA-guided human genome engineering via Cas9

Multiplex genome engineering using CRISPR/Cas systems

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

TopHat: discovering splice junctions with RNA-Seq

Trastuzumab emtansine for HER2-positive advanced breast cancer.

Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35)

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768-773

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scholarly article

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10.1038/NCHEMBIO.1590

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9

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Robert Kralovics

Oscar Fernandez-Capetillo

Branka Radic Sarikas

Cristina Mayor-Ruiz

Giulio Superti-Furga

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2014-07-27T00:00:00Z

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264289390

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25064833

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