BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.
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The Ikaros family of zinc-finger proteinsNSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL.STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress.Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia.Research and progress on ClC‑2 (Review).BCL6 is critical for the development of a diverse primary B cell repertoire.Short Stat5-interacting peptide derived from phospholipase C-β3 inhibits hematopoietic cell proliferation and myeloid differentiationFinding minimum gene subsets with heuristic breadth-first search algorithm for robust tumor classification.Pre-B cell receptor signaling induces immunoglobulin κ locus accessibility by functional redistribution of enhancer-mediated chromatin interactions.Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC.Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia.JAK and STAT signaling molecules in immunoregulation and immune-mediated disease.Cutting edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cellsIdentification and characterisation of the immune response properties of Lampetra japonica BLNK.Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function.Estrogen and insulin-like growth factor-I (IGF-I) independently down-regulate critical repressors of breast cancer growth.Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity.JAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia.The role of STAT5 in the development, function, and transformation of B and T lymphocytes.The role of STAT5 in lymphocyte development and transformationMechanisms of pre-B-cell receptor checkpoint control and its oncogenic subversion in acute lymphoblastic leukemia.The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia.BTK Signaling in B Cell Differentiation and Autoimmunity.STAT5 activation in B-cell acute lymphoblastic leukemia: damned if you do, damned if you don't.Downregulation of chloride channel ClC-2 by Janus kinase 3.Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway.Pre-B cell receptor signaling in acute lymphoblastic leukemia.Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemiaEffect of Janus kinase 3 on the peptide transporters PEPT1 and PEPT2.A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth.Biology and novel treatment options for XLA, the most common monogenetic immunodeficiency in man.Copy number profiling of adult relapsed B-cell precursor acute lymphoblastic leukemia reveals potential leukemia progression mechanisms.Regulation of Voltage-Gated K+ Channel Kv1.5 by the Janus Kinase JAK3.Upregulation of excitatory amino acid transporters by coexpression of Janus kinase 3.Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity.It is a differentiation game: STAT5 in a new role.
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P2860
BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.
@en
BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.
@nl
type
label
BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.
@en
BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.
@nl
prefLabel
BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.
@en
BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.
@nl
P2093
P2860
P1433
P1476
BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3
@en
P2093
Daisuke Kitamura
Hitoshi Satoh
Joji Nakayama
Katsuhiko Hayashi
Kenji Bundo
Masato Kubo
Mutsumi Yamamoto
Ryo Goitsuka
P2860
P304
P356
10.1182/BLOOD-2008-07-166355
P407
P577
2008-12-01T00:00:00Z