Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways

Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways

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http://www.wikidata.org/entity/Q37113524

Q37113524

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Targeting xenobiotic receptors PXR and CAR for metabolic diseases Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line: impact on sorafenib cytotoxicity A transcriptomic computational analysis of mastic oil-treated Lewis lung carcinomas reveals molecular mechanisms targeting tumor cell growth and survival Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells Dietary flavonoids activate the constitutive androstane receptor (CAR).Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.A novel xenobiotic responsive element regulated by aryl hydrocarbon receptor is involved in the induction of BCRP/ABCG2 in LS174T cells.Evaluation of metabolism-mediated herb-drug interactions.The Chinese herbal medicine Sophora flavescens activates pregnane X receptor Differential activation of pregnane X receptor and constitutive androstane receptor by buprenorphine in primary human hepatocytes and HepG2 cells.Pregnane X receptor-mediated induction of Cyp3a by black cohosh.Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice Echinacea purpurea up-regulates CYP1A2, CYP3A4 and MDR1 gene expression by activation of pregnane X receptor pathway.MicroRNA expression is differentially altered by xenobiotic drugs in different human cell lines.Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice Small-molecule modulators of the constitutive androstane receptor.Effect of ginkgo biloba on the pharmacokinetics of raltegravir in healthy volunteers Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation.Hepatocellular carcinomas in B6C3F1 mice treated with Ginkgo biloba extract for two years differ from spontaneous liver tumors in cancer gene mutations and genomic pathways Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells.Methadone induces the expression of hepatic drug-metabolizing enzymes through the activation of pregnane X receptor and constitutive androstane receptor.Indirect activation of the SV23 and SV24 splice variants of human constitutive androstane receptor: analysis with 3-hydroxyflavone and its analogues Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats Nuclear receptor-mediated alleviation of alcoholic fatty liver by polyphenols contained in alcoholic beverages.Toxicity and carcinogenicity studies of Ginkgo biloba extract in rat and mouse: liver, thyroid, and nose are targets.Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems.Induction of cytochrome P450 enzymes: a view on human in vivo findings.Theranostics meets traditional Chinese medicine: rational prediction of drug-herb interactions.Pharmacokinetic drug interactions involving Ginkgo biloba.Modulators of the human ABCC2: hope from natural sources?Differential impact of flavonoids on redox modulation, bioenergetics and cell signalling in normal and tumor cells: a comprehensive review.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.The regulation of human hepatic drug transporter expression by activation of xenobiotic-sensing nuclear receptors.Modulation of CYP1B1 and CYP1A1 gene expression and activation of aryl hydrocarbon receptor by Ginkgo biloba extract in MCF-10A human mammary epithelial cells.Effects of Gingko biloba extract on tissue distribution of fluoxetine and venlafaxine in rats.Antiproliferative effect of the Ginkgo biloba extract is associated with the enhancement of cytochrome P450 1B1 expression in estrogen receptor-negative breast cancer cells Effect of quercetin on P-glycoprotein transport ability in Chinese healthy subjects.Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and Ginkgo biloba extracts in healthy subjects.Modulation of Cytochrome P450, P-glycoprotein and Pregnane X Receptor by Selected Antimalarial Herbs-Implication for Herb-Drug Interaction.

P2860

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P2860

Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways

Item

http://www.wikidata.org/entity/Q37113524

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年学术文章

@wuu

2008年学术文章

@zh-cn

2008年学术文章

@zh-hans

2008年学术文章

@zh-my

2008年学术文章

@zh-sg

2008年學術文章

@yue

2008年學術文章

@zh

2008年學術文章

@zh-hant

name

Bioactive terpenoids and flavo ...... bon receptor-mediated pathways

@en

Bioactive terpenoids and flavo ...... on receptor-mediated pathways.

@nl

type

Item

label

Bioactive terpenoids and flavo ...... bon receptor-mediated pathways

@en

Bioactive terpenoids and flavo ...... on receptor-mediated pathways.

@nl

prefLabel

Bioactive terpenoids and flavo ...... bon receptor-mediated pathways

@en

Bioactive terpenoids and flavo ...... on receptor-mediated pathways.

@nl

P1476

Bioactive terpenoids and flavo ...... bon receptor-mediated pathways

@en

P2093

Antonia H Tolson

http://www.w3.org/2001/XMLSchema#string

Hongbing Wang

http://www.w3.org/2001/XMLSchema#string

Joseph D Stanton

http://www.w3.org/2001/XMLSchema#string

Linhao Li

http://www.w3.org/2001/XMLSchema#string

Yuan Luo

http://www.w3.org/2001/XMLSchema#string

P2860

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

Characterization of the Ah receptor mediating aryl hydrocarbon hydroxylase induction in the human liver cell line Hep G2

The Ginkgo Evaluation of Memory (GEM) study: design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia.

Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).

Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR.

P304

872-882

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P31

scholarly article

P356

10.1007/S11095-008-9788-8

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2008-11-26T00:00:00Z

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P5875

23498441

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P698

19034627

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P921

terpenoid

Ginkgo biloba

P932

2649697

http://www.w3.org/2001/XMLSchema#string

Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways

about

P2860

P2860

Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways

description

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P1433

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P2093

P2860

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P356

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P1433

P1476

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P932