Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.
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Alzheimer's disease as homeostatic responses to age-related myelin breakdownThe Rationale for Insulin Therapy in Alzheimer's DiseaseType 2 diabetes and cognitive impairment: linking mechanismsAlzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactionsAMPK: a cellular metabolic and redox sensor. A minireviewElevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brainTherapeutic targets of brain insulin resistance in sporadic Alzheimer's diseaseDrug repositioning approaches for the discovery of new therapeutics for Alzheimer's diseaseMetformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathyThe anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complexRole of anti-diabetic drugs as therapeutic agents in Alzheimer's diseaseBrain insulin resistance and deficiency as therapeutic targets in Alzheimer's diseaseA dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in miceEffects of AMP-activated protein kinase in cerebral ischemiaMetformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female miceExercise and cognitive function: a hypothesis for the association of type II diabetes mellitus and Alzheimer's disease from an evolutionary perspectiveMetformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice.Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons.Antioxidant and Anti-Senescence Effect of Metformin on Mouse Olfactory Ensheathing Cells (mOECs) May Be Associated with Increased Brain-Derived Neurotrophic Factor Levels-An Ex Vivo Study.AMPK activation--protean potential for boosting healthspan.AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.Berberine Ameliorates Diabetes-Associated Cognitive Decline through Modulation of Aberrant Inflammation Response and Insulin Signaling Pathway in DM Rats.Diabetes and the brain: issues and unmet needs.To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke RodentsRepurposing diabetes drugs for brain insulin resistance in Alzheimer disease.Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans.Metformin inhibits food intake and neuropeptide Y gene expression in the hypothalamusLinking cardiometabolic disorders to sporadic Alzheimer's disease: a perspective on potential mechanisms and mediators.Metformin in the diabetic brain: friend or foe?Diabetes, related conditions, and dementia.Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signalingIncreased risk of affective disorders in type 2 diabetes is minimized by sulfonylurea and metformin combination: a population-based cohort studyEffectiveness of medications used to attenuate antipsychotic-related weight gain and metabolic abnormalities: a systematic review and meta-analysisDifferential regulation of BACE1 expression by oxidative and nitrosative signalsAMPK at the nexus of energetics and aging.Insulin suppresses the expression of amyloid precursor protein, presenilins, and glycogen synthase kinase-3beta in peripheral blood mononuclear cells.Obesity, insulin resistance, and Alzheimer's disease.Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease.Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases
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Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 23 February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Antidiabetic drug metformin (G ...... egulating BACE1 transcription.
@en
Antidiabetic drug metformin
@nl
type
label
Antidiabetic drug metformin (G ...... egulating BACE1 transcription.
@en
Antidiabetic drug metformin
@nl
prefLabel
Antidiabetic drug metformin (G ...... egulating BACE1 transcription.
@en
Antidiabetic drug metformin
@nl
P2093
P2860
P356
P1476
Antidiabetic drug metformin (G ...... regulating BACE1 transcription
@en
P2093
Francesca-Fang Liao
Robert C Thompson
Ruishan Wang
Yaomin Chen
Yongbo Zhao
Young-Don Kwak
P2860
P304
P356
10.1073/PNAS.0807991106
P407
P577
2009-02-23T00:00:00Z