Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.
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Hyperpolarization-activated current, If, in mathematical models of rabbit sinoatrial node pacemaker cellsModern concepts concerning the origin of the heartbeat.Endosome-based protein trafficking and Ca(2+) homeostasis in the heartSudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop.Delayed afterdepolarization in intact canine sinoatrial node as a novel mechanism for atrial arrhythmia.Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells.Yin and yang of the cardiac pacemaker clock system in health and disease.A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.Funny current provides a relatively modest contribution to spontaneous beating rate regulation of human and rabbit sinoatrial node cells.A paradigm shift for the heart's pacemaker.Beat-to-beat cycle length variability of spontaneously beating guinea pig sinoatrial cells: relative contributions of the membrane and calcium clocks.Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cellsA novel quantitative explanation for the autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins.Sarcoplasmic reticulum Ca2+ pumping kinetics regulates timing of local Ca2+ releases and spontaneous beating rate of rabbit sinoatrial node pacemaker cells.Synergistic dual automaticity in sinoatrial node cell and tissue models.Rhythmic beating of stem cell-derived cardiac cells requires dynamic coupling of electrophysiology and Ca cycling.Synchronization of stochastic Ca²(+) release units creates a rhythmic Ca²(+) clock in cardiac pacemaker cellsThe role of the calcium and the voltage clocks in sinoatrial node dysfunction.Cellular cardiac electrophysiology modeling with Chaste and CellML.Ionic mechanisms underlying the negative chronotropic action of propofol on sinoatrial node automaticity in guinea pig heartIntegrative modeling of the cardiac ventricular myocyte.From two competing oscillators to one coupled-clock pacemaker cell systemA full range of mouse sinoatrial node AP firing rates requires protein kinase A-dependent calcium signaling.Spatiotemporal control of heart rate in a rabbit heart.The funny current in the context of the coupled-clock pacemaker cell system.Chronotropic Modulation of the Source-Sink Relationship of Sinoatrial-Atrial Impulse Conduction and Its Significance to Initiation of AF: A One-Dimensional Model Study.Modern perspectives on numerical modeling of cardiac pacemaker cellNumerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking.RyR-NCX-SERCA local cross-talk ensures pacemaker cell function at rest and during the fight-or-flight reflex.What keeps us ticking: a funny current, a calcium clock, or both?STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.Nonlinear dynamics in cardiology.Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells.The Popeye Domain Containing Genes and cAMP SignalingMechanisms of beat-to-beat regulation of cardiac pacemaker cell function by Ca²⁺ cycling dynamics.The Autonomic Nervous System Regulates the Heart Rate through cAMP-PKA Dependent and Independent Coupled-Clock Pacemaker Cell MechanismsCholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).Regulation of basal and reserve cardiac pacemaker function by interactions of cAMP-mediated PKA-dependent Ca2+ cycling with surface membrane channels.SERCA2a gene therapy in heart failure: an anti-arrhythmic positive inotrope.Effects of muscarinic receptor stimulation on Ca2+ transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells.
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P2860
Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 09 January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Synergism of coupled subsarcol ...... a novel pacemaker cell model.
@en
Synergism of coupled subsarcol ...... a novel pacemaker cell model.
@nl
type
label
Synergism of coupled subsarcol ...... a novel pacemaker cell model.
@en
Synergism of coupled subsarcol ...... a novel pacemaker cell model.
@nl
prefLabel
Synergism of coupled subsarcol ...... a novel pacemaker cell model.
@en
Synergism of coupled subsarcol ...... a novel pacemaker cell model.
@nl
P2860
P1476
Synergism of coupled subsarcol ...... n a novel pacemaker cell model
@en
P2860
P304
P356
10.1152/AJPHEART.01118.2008
P577
2009-01-09T00:00:00Z