about
Na+ channel function, regulation, structure, trafficking and sequestrationModern concepts concerning the origin of the heartbeat.Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node CellsNovel, ultraslow inactivating sodium current in human ventricular cardiomyocytesDifferentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrinLife and death of a cardiac calcium sparkDiastolic calcium release controls the beating rate of rabbit sinoatrial node cells: numerical modeling of the coupling process.A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.A novel quantitative explanation for the autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins.Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity.Calpain inhibition reduces amplitude and accelerates decay of the late sodium current in ventricular myocytes from dogs with chronic heart failureCyclic variation of intracellular calcium: a critical factor for cardiac pacemaker cell dominance.Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rateBeat-to-beat Ca(2+)-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm.The funny current in the context of the coupled-clock pacemaker cell system.Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability.Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking.Normal heart rhythm is initiated and regulated by an intracellular calcium clock within pacemaker cellsRhythmic Ca2+ oscillations drive sinoatrial nodal cell pacemaker function to make the heart tick.Late sodium current in failing heart: friend or foe?The integration of spontaneous intracellular Ca2+ cycling and surface membrane ion channel activation entrains normal automaticity in cells of the heart's pacemaker.Post-transcriptional alterations in the expression of cardiac Na+ channel subunits in chronic heart failure.Calcium signalling in individual T-cells measured by confocal microscopy.New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: bradycardic effects of ivabradine are linked to suppression of intracellular Ca²⁺ cycling.The missing link in the mystery of normal automaticity of cardiac pacemaker cells.Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model.Mechanisms of beat-to-beat regulation of cardiac pacemaker cell function by Ca²⁺ cycling dynamics.Late Na+ current produced by human cardiac Na+ channel isoform Nav1.5 is modulated by its beta1 subunit.Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).Numerical Modeling Calcium and CaMKII Effects in the SA Node.Rebuttal: what I(f) the shoe doesn't fit? "The funny current has a major pacemaking role in the sinus node".Development of cardiomyocytes expressing cardiac-specific genes, action potentials, and ionic channels during embryonic stem cell-derived cardiogenesis.Embryonic stem cells: a model to study structural and functional properties in cardiomyogenesis.Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents.Stabilization of diastolic calcium signal via calcium pump regulation of complex local calcium releases and transient decay in a computational model of cardiac pacemaker cell with individual release channels.Muscle cell differentiation of embryonic stem cells reflects myogenesis in vivo: developmentally regulated expression of myogenic determination genes and functional expression of ionic currents.Reprogramming paces the heart.Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cellsEstablishment of beta-adrenergic modulation of L-type Ca2+ current in the early stages of cardiomyocyte development.Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.
P50
Q27005721-12D46697-C7B1-46C6-B74D-6B3AFB1ED4BBQ27008871-71DE00C1-FE1C-4346-8779-E6A9133FFF59Q27312304-621AF7B6-E882-4F8E-9A21-E14249E5239FQ28290775-F23F5430-BBC2-4BC0-A00F-61461F647925Q28591675-5DF6EA49-6F2F-4BBA-BFD0-2E8920AB6F08Q28681451-2D445FA3-1825-454B-AFE2-35D281CFE501Q33200126-E082409E-57ED-49E4-987D-855BFA18B241Q33722486-E9C169FD-610F-49EA-A201-4C3F1E70D518Q33917214-A06A4366-A5E5-47B6-A112-A9C385AEC9BCQ34292535-0691A625-4CC7-4957-AE35-C0E66BA07B53Q34676097-B8F72F23-77D3-401C-9865-51FA650D3CD2Q35069469-806E22D7-EEC7-42DA-90C0-59A7B2255AACQ35078344-258A5DCD-6822-45F9-AF85-056101390785Q35529322-93758FA4-EB8F-423B-9023-69B3552094CCQ35705710-649443D2-9609-4DFE-9966-6A394FD0D510Q35741443-D1156390-4891-4E49-9AE6-0E26A99C462CQ35961500-A486DC03-D1D2-4D63-A2D1-0BAF9F631D32Q36144968-19AAD956-04F0-44E6-851C-924358C872F5Q36225130-80D45422-6C09-4671-B434-2D359F10056DQ36496273-CC02E7FC-11D2-48EE-8F52-5F2817635B9DQ36667321-A4ECD26E-8B22-4F8A-B4D8-66ACCA7A6C3AQ36691828-0544F557-C8EC-4513-9B48-070D3F2386C7Q36713216-AD656080-5E6A-4887-8F1C-6636AA5A902FQ37075876-6CF6B2A8-E4E7-43E1-81F6-D83A9B988A28Q37122795-25530CD6-606C-4A3B-A7AA-E85D460A2D89Q37138978-2E5A917F-D2CD-4056-A57B-6C99C2066267Q37217198-3200AC20-08CD-487D-B258-65C2D2146CF5Q37347227-5B002757-053C-4436-9145-9E0A55F77147Q37372389-4545AD5B-F24E-4F80-A6E8-BDF71298C07EQ37689500-C597E473-C2F7-4F1D-B067-3E0280FC75ECQ38549676-EF2C76EF-C986-4E18-8FDC-7F630E927110Q40400782-EAF56249-3C46-468E-8562-8346DB3185CAQ41065461-394D5A73-2FE6-4532-A299-51D9C8CDF09AQ41451209-4B6AA608-D336-4CBD-9231-40CADD06EA2EQ41456202-87D7ADC8-C098-4B72-9BD5-1EFB30D3FEE0Q41456800-35FED81B-078A-4234-B24D-B7EB068E4DD5Q42082753-61297583-95CA-4B8D-80AC-61C27231526CQ42363527-2F84285B-7023-452A-82CB-893612EA9437Q42467529-AF98ACED-C350-4406-8400-5A39E28013FDQ42470431-6979D456-B709-426D-9321-0B445FCEF8BE
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Victor A. Maltsev
@ast
Victor A. Maltsev
@en
Victor A. Maltsev
@es
Victor A. Maltsev
@sl
type
label
Victor A. Maltsev
@ast
Victor A. Maltsev
@en
Victor A. Maltsev
@es
Victor A. Maltsev
@sl
prefLabel
Victor A. Maltsev
@ast
Victor A. Maltsev
@en
Victor A. Maltsev
@es
Victor A. Maltsev
@sl
P106
P1153
7005644867
P21
P31
P496
0000-0002-3832-791X