An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a
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Targeting Transcriptional Regulators of CD8+ T Cell Dysfunction to Boost Anti-Tumor ImmunityEndogenous retroviruses and the development of cancerMicroRNA regulation of lymphocyte tolerance and autoimmunityEffective T helper cell responses against retroviruses: are all clonotypes equal?MicroRNA regulation of T-lymphocyte immunity: modulation of molecular networks responsible for T-cell activation, differentiation, and developmentAre human endogenous retroviruses pathogenic? An approach to testing the hypothesisDynamic nature of noncoding RNA regulation of adaptive immune responseIndoctrinating T cells to attack pathogens through homeschoolingStructural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c-I-EEffect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand SpecificityDeconstructing the Peptide-MHC Specificity of T Cell RecognitionmiR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)Highlights of the advances in basic immunology in 2011.Physiological numbers of CD4+ T cells generate weak recall responses following influenza virus challengeSystemic delivery of microRNA-181b inhibits nuclear factor-κB activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice.Epitope density influences CD8+ memory T cell differentiation.Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection.The ability to rearrange dual TCRs enhances positive selection, leading to increased Allo- and Autoreactive T cell repertoires.Fine-tuning T cell receptor signaling to control T cell developmentDynamic modulation of thymic microRNAs in response to stress.Revisiting thymic positive selection and the mature T cell repertoire for antigen.Dynamic microRNA gene transcription and processing during T cell development.Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection.How the immune system talks to itself: the varied role of synapsesDicer controls CD8+ T-cell activation, migration, and survival.Thymus-specific serine protease contributes to the diversification of the functional endogenous CD4 T cell receptor repertoire.Self-pMHCII complexes are variably expressed in the thymus and periphery independent of mRNA expression but dependent on the activation state of the APCsMiR-181a regulates inflammation responses in monocytes and macrophagesOn the issue of peptide recognition in T cell development.Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8.The roles of microRNAs on tuberculosis infection: meaning or myth?T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters.MicroRNA control of lymphocyte differentiation and functionUpdate on non-canonical microRNAs.The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression.CD4⁺CD25⁺Foxp3⁺ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletionmicroRNAs regulate cell-to-cell variability of endogenous target gene expression in developing mouse thymocytes.MicroRNA-deficient NK cells exhibit decreased survival but enhanced function
P2860
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P2860
An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 04 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
An endogenous positively selec ...... e absence of microRNA miR-181a
@en
An endogenous positively selec ...... absence of microRNA miR-181a.
@nl
type
label
An endogenous positively selec ...... e absence of microRNA miR-181a
@en
An endogenous positively selec ...... absence of microRNA miR-181a.
@nl
prefLabel
An endogenous positively selec ...... e absence of microRNA miR-181a
@en
An endogenous positively selec ...... absence of microRNA miR-181a.
@nl
P2093
P2860
P356
P1433
P1476
An endogenous positively selec ...... e absence of microRNA miR-181a
@en
P2093
Mark M Davis
Peter J R Ebert
Qi-Jing Li
Shan Jiang
P2860
P304
P356
10.1038/NI.1797
P407
P50
P577
2009-10-04T00:00:00Z