WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis. - Test2 - elhamkhani - TriplyDB

WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis.

WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis.

http://www.wikidata.org/entity/Q37167514

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HYAL-2-WWOX-SMAD4 Signaling in Cell Death and Anticancer Response Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed.Role of WW Domain-containing Oxidoreductase WWOX in Driving T Cell Acute Lymphoblastic Leukemia Maturation.Zfra restores memory deficits in Alzheimer's disease triple-transgenic mice by blocking aggregation of TRAPPC6AΔ, SH3GLB2, tau, and amyloid β, and inflammatory NF-κB activation.A cascade of protein aggregation bombards mitochondria for neurodegeneration and apoptosis under WWOX deficiency.Phosphorylation/de-phosphorylation in specific sites of tumor suppressor WWOX and control of distinct biological events.The immunoproteasome is induced by cytokines and regulates apoptosis in human islets.Chasing the signaling run by tri-molecular time-lapse FRET microscopy.WWOX Phosphorylation, Signaling, and Role in Neurodegeneration

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WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis.

http://www.wikidata.org/entity/Q37167514

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 03 August 2015

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

WWOX dysfunction induces seque ...... yloid β, and causes apoptosis.

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WWOX dysfunction induces seque ...... yloid β, and causes apoptosis.

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type

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WWOX dysfunction induces seque ...... yloid β, and causes apoptosis.

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WWOX dysfunction induces seque ...... yloid β, and causes apoptosis.

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prefLabel

WWOX dysfunction induces seque ...... yloid β, and causes apoptosis.

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WWOX dysfunction induces seque ...... yloid β, and causes apoptosis.

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CDDISCOVERY.2015.3

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Cell death discovery

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WWOX dysfunction induces seque ...... yloid β, and causes apoptosis.

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J-Y Chang

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N-S Chang

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Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response

Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity

Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1

The TRAPP complex: insights into its architecture and function

Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity

JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis

Expression of WW domain-containing oxidoreductase WOX1 in the developing murine nervous system

Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease

Dramatic co-activation of WWOX/WOX1 with CREB and NF-kappaB in delayed loss of small dorsal root ganglion neurons upon sciatic nerve transection in rats

TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease.

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cddiscovery.2015.3

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10.1038/CDDISCOVERY.2015.3

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apoptotic process

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