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A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivoUsefulness of lipid apheresis in the treatment of familial hypercholesterolemiaAnnexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradationMechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pHIdentification of heterogeneous nuclear ribonucleoprotein K as a transactivator for human low density lipoprotein receptor gene transcriptionMMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cellsGPIHBP1 is responsible for the entry of lipoprotein lipase into capillariesThe PCSK9 decadeActivation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoterPCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primatesInhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levelsUnmet Needs in LDL-C Lowering: When Statins Won't Do!Challenges in the Diagnosis and Treatment of Homozygous Familial HypercholesterolemiaStatins: definitive translational researchFrom evolution to revolution: miRNAs as pharmacological targets for modulating cholesterol efflux and reverse cholesterol transportUbiquitin ligases in cholesterol metabolismMechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease riskFamilial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis SocietyLoss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulationA proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primatesIdentification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein ReceptorNew Era of Lipid-Lowering DrugsA century of cholesterol and coronaries: from plaques to genes to statinsLow-normal thyroid function and novel cardiometabolic biomarkersPCSK6-mediated corin activation is essential for normal blood pressureSEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion.Very low LDL-C levels may safely provide additional clinical cardiovascular benefit: the evidence to dateWhole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.Molecular analysis and intestinal expression of SAR1 genes and proteins in Anderson's disease (Chylomicron retention disease)IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.New cholesterol guidelines: worth the wait?Genome-wide expression profiling deciphers host responses altered during dengue shock syndrome and reveals the role of innate immunity in severe dengue.Advances in dyslipidemia management for prevention of atherosclerosis: PCSK9 monoclonal antibody therapy and beyondEfficacy and safety of proprotein convertase subtilisin/kexin type 9 monoclonal antibody in adults with familial hypercholesterolemiaGenetic determinants of inherited susceptibility to hypercholesterolemia - a comprehensive literature review.Heterozygous Familial Hypercholesterolemia With APOE Haplotype: A Prospective Harbinger of a Catastrophic Cardiovascular Event.Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey.PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway.Cholesterol, the central lipid of mammalian cellsA Highly Durable RNAi Therapeutic Inhibitor of PCSK9.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
PCSK9: a convertase that coordinates LDL catabolism.
@en
PCSK9: a convertase that coordinates LDL catabolism.
@nl
type
label
PCSK9: a convertase that coordinates LDL catabolism.
@en
PCSK9: a convertase that coordinates LDL catabolism.
@nl
prefLabel
PCSK9: a convertase that coordinates LDL catabolism.
@en
PCSK9: a convertase that coordinates LDL catabolism.
@nl
P2093
P2860
P1476
PCSK9: a convertase that coordinates LDL catabolism.
@en
P2093
Helen H Hobbs
Jay D Horton
Jonathan C Cohen
P2860
P304
P356
10.1194/JLR.R800091-JLR200
P478
P577
2008-11-19T00:00:00Z