Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells.
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Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disordersLeptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's diseaseThe Possible Roles of the Dentate Granule Cell's Leptin and Other Ciliary Receptors in Alzheimer's NeuropathologyMetabolic reserve as a determinant of cognitive agingAMPK: a cellular metabolic and redox sensor. A minireviewAcute leptin treatment enhances functional recovery after spinal cord injuryLowering glucose level elevates [Ca2+]i in hypothalamic arcuate nucleus NPY neurons through P/Q-type Ca2+ channel activation and GSK3β inhibition.Estrogen: a master regulator of bioenergetic systems in the brain and bodyLow plasma leptin in cognitively impaired ADNI subjects: gender differences and diagnostic and therapeutic potential.The therapeutic potential of metabolic hormones in the treatment of age-related cognitive decline and Alzheimer's disease.Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slicesβ-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathwayGSK-3 in Neurodegenerative Diseases.Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction.Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus.Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease.Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseasesLeptin signaling and Alzheimer's disease.Obesity, leptin, and Alzheimer's diseaseLeptin Dysfunction and Alzheimer's Disease: Evidence from Cellular, Animal, and Human Studies.Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots.Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance.Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy?An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders.Neuronal models for studying tau pathology.AMP-activated protein kinase: a potential player in Alzheimer's disease.Neuroglialpharmacology: myelination as a shared mechanism of action of psychotropic treatments.Roles of AMP-activated protein kinase in Alzheimer's disease.Neuroendocrinology-based therapy for Alzheimer's disease.Cellular Links between Neuronal Activity and Energy Homeostasis.Obesity as a risk factor for Alzheimer's disease: the role of adipocytokines.Association of glycogen synthase kinase-3β with Parkinson's disease (review).Minireview: Food for thought: regulation of synaptic function by metabolic hormones.Activation of the 5'-AMP-Activated Protein Kinase in the Cerebral Cortex of Young Senescence-Accelerated P8 Mice and Association with GSK3β- and PP2A-Dependent Inhibition of p-tau₃₉₆ Expression.The Neuroprotective Effects of Justicidin A on Amyloid Beta25-35-Induced Neuronal Cell Death Through Inhibition of Tau Hyperphosphorylation and Induction of Autophagy in SH-SY5Y Cells.Leptin signaling plays a critical role in the geniposide-induced decrease of tau phosphorylation.Protective effect of leptin and ghrelin against toxicity induced by amyloid-β oligomers in a hypothalamic cell line.Activation of AMP-activated protein kinase alleviates homocysteine-mediated neurotoxicity in SH-SY5Y cells.Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol.Leptin: a novel therapeutic target in Alzheimer's disease?
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Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 25 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Leptin inhibits glycogen synth ...... phorylation in neuronal cells.
@en
Leptin inhibits glycogen synth ...... phorylation in neuronal cells.
@nl
type
label
Leptin inhibits glycogen synth ...... phorylation in neuronal cells.
@en
Leptin inhibits glycogen synth ...... phorylation in neuronal cells.
@nl
prefLabel
Leptin inhibits glycogen synth ...... phorylation in neuronal cells.
@en
Leptin inhibits glycogen synth ...... phorylation in neuronal cells.
@nl
P2093
P2860
P1433
P1476
Leptin inhibits glycogen synth ...... phorylation in neuronal cells.
@en
P2093
Gemma Casadesus
J Wesson Ashford
Jane M Johnston
Nikolaos Tezapsidis
Sraboni Sarkar
Steven J Greco
P2860
P304
P356
10.1016/J.NEULET.2009.03.066
P407
P577
2009-03-25T00:00:00Z