Selection of H5N1 influenza virus PB2 during replication in humans. - Test2 - elhamkhani - TriplyDB

Selection of H5N1 influenza virus PB2 during replication in humans.

Selection of H5N1 influenza virus PB2 during replication in humans.

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Human H7N9 avian influenza virus infection: a review and pandemic risk assessment Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus Changes in the hemagglutinin of H5N1 viruses during human infection – Influence on receptor binding Conformational polymorphism of m7GTP in crystal structure of the PB2 middle domain from human influenza A virus Use of highly pathogenic avian influenza A(H5N1) gain-of-function studies for molecular-based surveillance and pandemic preparedness.Emergence of the virulence-associated PB2 E627K substitution in a fatal human case of highly pathogenic avian influenza virus A(H7N7) infection as determined by Illumina ultra-deep sequencing.Analysis of recombinant H7N9 wild-type and mutant viruses in pigs shows that the Q226L mutation in HA is important for transmission PB2 mutations D701N and S714R promote adaptation of an influenza H5N1 virus to a mammalian host Substitution of lysine at 627 position in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice OpenFluDB, a database for human and animal influenza virus.The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice.Impact of amino acid mutations in PB2, PB1-F2, and NS1 on the replication and pathogenicity of pandemic (H1N1) 2009 influenza viruses Genetic composition of contemporary swine influenza viruses in the West Central region of the United States of America.Polymerase activity of hybrid ribonucleoprotein complexes generated from reassortment between 2009 pandemic H1N1 and seasonal H3N2 influenza A viruses.Phylogenetic diversity and genotypic complexity of H1N1 subtype swine influenza viruses isolated in mainland China Asparagine substitution at PB2 residue 701 enhances the replication, pathogenicity, and transmission of the 2009 pandemic H1N1 influenza A virus.Detection of mammalian virulence determinants in highly pathogenic avian influenza H5N1 viruses: multivariate analysis of published data.T-705 (favipiravir) activity against lethal H5N1 influenza A viruses Characterization of H5N1 influenza viruses isolated from humans in vitro.Genomic and protein structural maps of adaptive evolution of human influenza A virus to increased virulence in the mouse.The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.Role of position 627 of PB2 and the multibasic cleavage site of the hemagglutinin in the virulence of H5N1 avian influenza virus in chickens and ducks.Emergence of fatal avian influenza in New England harbor seals Molecular basis of efficient replication and pathogenicity of H9N2 avian influenza viruses in mice.Highly pathogenic H5N1 influenza A virus strains provoke heterogeneous IFN-α/β responses that distinctively affect viral propagation in human cells.Virulence of H5N1 virus in mice attenuates after in vitro serial passages.Interaction of the influenza A virus polymerase PB2 C-terminal region with importin alpha isoforms provides insights into host adaptation and polymerase assembly.Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.Amino acid residues 253 and 591 of the PB2 protein of avian influenza virus A H9N2 contribute to mammalian pathogenesis.Equine and Canine Influenza H3N8 Viruses Show Minimal Biological Differences Despite Phylogenetic Divergence.New reassortant H5N8 highly pathogenic avian influenza virus from waterfowl in Southern China Pathogenicity of the novel A/H7N9 influenza virus in mice.Mammalian adaptation in the PB2 gene of avian H5N1 influenza virus Ostrich involvement in the selection of H5N1 influenza virus possessing mammalian-type amino acids in the PB2 protein.Multiple introductions of highly pathogenic avian influenza H5N1 viruses into Bangladesh.Amino acid substitutions in polymerase basic protein 2 gene contribute to the pathogenicity of the novel A/H7N9 influenza virus in mammalian hosts.Interspecies and intraspecies transmission of influenza A viruses: viral, host and environmental factors.Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase.Genetic Adaptation of Influenza A Viruses in Domestic Animals and Their Potential Role in Interspecies Transmission: A Literature Review.

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P2860

Selection of H5N1 influenza virus PB2 during replication in humans.

http://www.wikidata.org/entity/Q37192151

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 04 March 2009

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

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name

Selection of H5N1 influenza virus PB2 during replication in humans.

@en

Selection of H5N1 influenza virus PB2 during replication in humans.

@nl

type

label

Selection of H5N1 influenza virus PB2 during replication in humans.

@en

Selection of H5N1 influenza virus PB2 during replication in humans.

@nl

prefLabel

Selection of H5N1 influenza virus PB2 during replication in humans.

@en

Selection of H5N1 influenza virus PB2 during replication in humans.

@nl

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Journal of Virology

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Selection of H5N1 influenza virus PB2 during replication in humans.

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P2093

Makoto Ozawa

http://www.w3.org/2001/XMLSchema#string

Mustumi Ito

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Quynh Mai Le

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P2860

Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome

Evolution of influenza A virus PB2 genes: implications for evolution of the ribonucleoprotein complex and origin of human influenza A virus

Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses

Evolution of pig influenza viruses.

Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors.

Persistent host markers in pandemic and H5N1 influenza viruses

Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice.

Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N.

Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus

Molecular correlates of influenza A H5N1 virus pathogenesis in mice.

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5278-5281

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scholarly article

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10.1128/JVI.00063-09

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10

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83

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Yoshihiro Kawaoka

Yuko Sakai-Tagawa

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2009-03-04T00:00:00Z

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19264775

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2682078

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