The topography of mutational processes in breast cancer genomes. - Test2 - elhamkhani - TriplyDB

The topography of mutational processes in breast cancer genomes.

The topography of mutational processes in breast cancer genomes.

http://www.wikidata.org/entity/Q37211361

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DNA Repair Pathway Alterations in Bladder Cancer.Progressive APOBEC3B mRNA expression in distant breast cancer metastases.When Genome Maintenance Goes Badly Awry.The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.Reactivation of dormant anti-tumor immunity - a clinical perspective of therapeutic immune checkpoint modulation.Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity Chromatin Dynamics in Genome Stability: Roles in Suppressing Endogenous DNA Damage and Facilitating DNA Repair Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups.Human mismatch repair system balances mutation rates between strands by removing more mismatches from the lagging strand.Deciphering and Targeting Oncogenic Mutations and Pathways in Breast Cancer.Hereditary breast and ovarian cancer: new genes in confined pathways.APOBEC3A/B-induced mutagenesis is responsible for 20% of heritable mutations in the TpCpW context.Perturbations in the Replication Program Contribute to Genomic Instability in Cancer.Comparative clinical utility of tumor genomic testing and cell-free DNA in metastatic breast cancer.A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers.Elementary: breast cancer culprits leave their signatures on the double helix.Avoidance of APOBEC3B-induced mutation by error-free lesion bypass BLIP-II Employs Differential Hotspot Residues To Bind Structurally Similar Staphylococcus aureus PBP2a and Class A β-Lactamases.Breast cancers are rare diseases-and must be treated as such.BeWith: A Between-Within method to discover relationships between cancer modules via integrated analysis of mutual exclusivity, co-occurrence and functional interactions Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis.Reduced mutation rate in exons due to differential mismatch repair.Comprehensive Analysis of Hypermutation in Human Cancer.Detecting presence of mutational signatures in cancer with confidence.The diverse functions of the hepatitis B core/capsid protein (HBc) in the viral life cycle: Implications for the development of HBc-targeting antivirals.Viral subversion of APOBEC3s: Lessons for anti-tumor immunity and tumor immunotherapy.Computational approaches for discovery of mutational signatures in cancer.Detection and genomic characterization of a mammary-like adenocarcinoma.HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.Nuclear topology modulates the mutational landscapes of cancer genomes.Short inverted repeats contribute to localized mutability in human somatic cells.Integrated Microarray-based Tools for Detection of Genomic DNA Damage and Repair Mechanisms.Within-Host Variations of Human Papillomavirus Reveal APOBEC-Signature Mutagenesis in the Viral Genome.An integrative bioinformatics approach reveals coding and non-coding gene variants associated with gene expression profiles and outcome in breast cancer molecular subtypes.Correlation of gene expression and associated mutation profiles of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT with chemosensitivity of cancer cell lines to drug treatment.Modeling cancer rearrangement landscapes.Validating the concept of mutational signatures with isogenic cell models.Therapeutic landscape in mutational triple negative breast cancer Mutational signature distribution varies with DNA replication timing and strand asymmetry Recent advances in understanding the complexities of metastasis

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The topography of mutational processes in breast cancer genomes.

http://www.wikidata.org/entity/Q37211361

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 02 May 2016

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

The topography of mutational processes in breast cancer genomes.

@en

The topography of mutational processes in breast cancer genomes.

@nl

type

label

The topography of mutational processes in breast cancer genomes.

@en

The topography of mutational processes in breast cancer genomes.

@nl

prefLabel

The topography of mutational processes in breast cancer genomes.

@en

The topography of mutational processes in breast cancer genomes.

@nl

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Nature Communications

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The topography of mutational processes in breast cancer genomes.

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Adam Butler

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Alastair M Thompson

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Andrea L Richardson

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Anieta M Sieuwerts

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Arie B Brinkman

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Christos Sotiriou

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Cristina Rada

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Gilles Thomas

http://www.w3.org/2001/XMLSchema#string

Gu Kong

http://www.w3.org/2001/XMLSchema#string

Helen Davies

http://www.w3.org/2001/XMLSchema#string

P2860

An integrated encyclopedia of DNA elements in the human genome

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

Making sense of eukaryotic DNA replication origins.

Mutational processes molding the genomes of 21 breast cancers

A comprehensive catalogue of somatic mutations from a human cancer genome

NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity

Genome instability: a mechanistic view of its causes and consequences

Deciphering signatures of mutational processes operative in human cancer

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

Signatures of mutational processes in human cancer

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11383

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10.1038/NCOMMS11383

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7

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Anne-Lise Børresen-Dale

Serena Nik-Zainal

Ludmil B. Alexandrov

Marc van de Vijver

Sunil R Lakhani

Sandro Morganella

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2016-05-02T00:00:00Z

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27136393

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