Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
about
Trial watch - inhibiting PARP enzymes for anticancer therapyC1D family proteins in coordinating RNA processing, chromosome condensation and DNA damage responseHomologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian CancerExploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer TherapyDNA polymerase θ (POLQ), double-strand break repair, and cancerDNA Polymerase θ: A Unique Multifunctional End-Joining MachineHomeodomain-Interacting Protein Kinase-2: A Critical Regulator of the DNA Damage Response and the EpigenomeNoncanonical views of homology-directed DNA repairSnaps and mends: DNA breaks and chromosomal translocationsMicrohomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB RepairMicrohomology-mediated end joining: new players join the teamEnhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for CancerA phase I study of intravenous and oral rucaparib in combination with chemotherapy in patients with advanced solid tumoursMicrohomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex.Drugging the Cancers Addicted to DNA Repair.Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repairDNA polymerases in the mitochondria: A critical review of the evidence.Error-Prone Repair of DNA Double-Strand Breaks.Induction of DNA damage and erroneous repair can explain genomic instability caused by endosulfan.Human DNA polymerase θ grasps the primer terminus to mediate DNA repairPolymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesisSmall-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.Identification of Anti-CA125 Antibody Responses in Ovarian Cancer Patients by a Novel Deep Sequence-Coupled Biopanning Platform.Deciphering the BRCA1 Tumor Suppressor Network.EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair.Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks.Poly (ADP-ribose) polymerase inhibitors: recent advances and future development.A role for human homologous recombination factors in suppressing microhomology-mediated end joiningMechanistic Modelling and Bayesian Inference Elucidates the Variable Dynamics of Double-Strand Break Repair.Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining.NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres.FANCA safeguards interphase and mitosis during hematopoiesis in vivo.Linking DNA polymerase theta structure and function in health and diseaseComplex interactions between the DNA-damage response and mammalian telomeres.High Quality Maize Centromere 10 Sequence Reveals Evidence of Frequent Recombination Events.RECQL: a new breast cancer susceptibility gene.Repair Pathway Choices and Consequences at the Double-Strand BreakSister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4.Risky business: Microhomology-mediated end joining.
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P2860
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
description
2015 nî lūn-bûn
@nan
2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
@ast
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
@en
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
@en-gb
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
@nl
type
label
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
@ast
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
@en
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
@en-gb
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
@nl
prefLabel
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
@ast
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
@en
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
@en-gb
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
@nl
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P3181
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Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
@en
P2093
Alan D D'Andrea
Benjamin Primack
Ildiko Hajdu
Jessica C Liu
Kevin W O'Connor
Panagiotis A Konstantinopoulos
Raphael Ceccaldi
Ravindra Amunugama
Simon J Boulton
Timur Yusufzai
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P2888
P304
P3181
P356
10.1038/NATURE14184
P407
P577
2015-02-12T00:00:00Z
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P6179
1008328471