BRCA1 and BRCA2 genetic testing-pitfalls and recommendations for managing variants of uncertain clinical significance.
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NIH working group report-using genomic information to guide weight management: From universal to precision treatmentFindings made in gene panel to whole genome sequencing: data, knowledge, ethics - and consequences?Awareness, knowledge, perceptions, and attitudes towards genetic testing for cancer risk among ethnic minority groups: a systematic review.Functional classification of DNA variants by hybrid minigenes: Identification of 30 spliceogenic variants of BRCA2 exons 17 and 18.Implementing rapid, robust, cost-effective, patient-centred, routine genetic testing in ovarian cancer patientsTargeted sequencing of BRCA1 and BRCA2 across a large unselected breast cancer cohort suggests that one-third of mutations are somaticData sharing as a national quality improvement program: reporting on BRCA1 and BRCA2 variant-interpretation comparisons through the Canadian Open Genetics Repository (COGR).Classification and Clinical Management of Variants of Uncertain Significance in High Penetrance Cancer Predisposition Genes.Selecting Patients with Ovarian Cancer for Germline BRCA Mutation Testing: Findings from Guidelines and a Systematic Literature Review.Health Care Disparities in Hereditary Ovarian Cancer: Are We Reaching the Underserved Population?Hereditary breast and ovarian cancer: new genes in confined pathways.Therapeutic targeting and patient selection for cancers with homologous recombination defects.BRCA Share: A Collection of Clinical BRCA Gene Variants.Conflicting Interpretation of Genetic Variants and Cancer Risk by Commercial Laboratories as Assessed by the Prospective Registry of Multiplex Testing.Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer.Health care professionals' attitudes towards population-based genetic testing and risk-stratification for ovarian cancer: a cross-sectional survey.Traceback: A Proposed Framework to Increase Identification and Genetic Counseling of BRCA1 and BRCA2 Mutation Carriers Through Family-Based Outreach.Genetic testing in women with breast cancer: implications for treatment.Spectrum of genetic variants of BRCA1 and BRCA2 in a German single center study.Germline genetic variants with implications for disease risk and therapeutic outcomes.Combined annotation-dependent depletion score for BRCA1/2 variants in patients with breast and/or ovarian cancer.CDH1 mutation screen in a BRCA1/2-negative familial breast-/ovarian cancer cohort.Recommendations for biomarker testing in epithelial ovarian cancer: a National Consensus Statement by the Spanish Society of Pathology and the Spanish Society of Medical Oncology.Changes in classification of genetic variants in BRCA1 and BRCA2.From the laboratory to the clinic: sharing BRCA VUS reclassification tools with practicing genetics professionals.A comparison of cancer risk assessment and testing outcomes in patients from underserved vs. tertiary care settings.Somatic BRCA1 mutations in clinically sporadic breast cancer with medullary histological features.Patient-Centered Care in Breast Cancer Genetic Clinics.Performance of in silico prediction tools for the classification of rare BRCA1/2 missense variants in clinical diagnostics.Dealing With BRCA1/2 Unclassified Variants in a Cancer Genetics Clinic: Does Cosegregation Analysis Help?Computational Tools for Splicing Defect Prediction in Breast/Ovarian Cancer Genes: How Efficient Are They at Predicting RNA Alterations?
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BRCA1 and BRCA2 genetic testing-pitfalls and recommendations for managing variants of uncertain clinical significance.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 07 July 2015
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
BRCA1 and BRCA2 genetic testin ...... certain clinical significance.
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BRCA1 and BRCA2 genetic testin ...... certain clinical significance.
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type
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BRCA1 and BRCA2 genetic testin ...... certain clinical significance.
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BRCA1 and BRCA2 genetic testin ...... certain clinical significance.
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altLabel
BRCA1 and BRCA2 genetic testin ...... ncertain clinical significance
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BRCA1andBRCA2genetic testing—p ...... ncertain clinical significance
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prefLabel
BRCA1 and BRCA2 genetic testin ...... certain clinical significance.
@en
BRCA1 and BRCA2 genetic testin ...... certain clinical significance.
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BRCA1 and BRCA2 genetic testin ...... certain clinical significance.
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D M Eccles
E B Gómez-García
ENIGMA Clinical Working Group
G Mitchell
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P304
P356
10.1093/ANNONC/MDV278
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P577
2015-07-07T00:00:00Z