Quantitative electroencephalography within sleep/wake states differentiates GABAA modulators eszopiclone and zolpidem from dual orexin receptor antagonists in rats.
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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomniaInhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in MonkeysDifferential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulatorsOrexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs.Electroencephalographic power spectral density profile of the orexin receptor antagonist suvorexant in patients with primary insomnia and healthy subjects.Enhanced slow-wave EEG activity and thermoregulatory impairment following the inhibition of the lateral hypothalamus in the rat.The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold.State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effectsDual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators.Orexin OX2 Receptor Antagonists as Sleep Aids.Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors.The dual orexin receptor antagonist, DORA-22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine.Pharmacological evaluation of orexin receptor antagonists in preclinical animal models of pain.Orexin Receptor Antagonists
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Quantitative electroencephalography within sleep/wake states differentiates GABAA modulators eszopiclone and zolpidem from dual orexin receptor antagonists in rats.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 31 May 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Quantitative electroencephalog ...... receptor antagonists in rats.
@en
Quantitative electroencephalog ...... receptor antagonists in rats.
@nl
type
label
Quantitative electroencephalog ...... receptor antagonists in rats.
@en
Quantitative electroencephalog ...... receptor antagonists in rats.
@nl
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Quantitative electroencephalog ...... receptor antagonists in rats.
@en
Quantitative electroencephalog ...... receptor antagonists in rats.
@nl
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Quantitative electroencephalog ...... receptor antagonists in rats.
@en
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Alan T Savitz
Anthony L Gotter
Christopher J Winrow
Jason M Uslaner
John J Renger
Joseph I Brunner
Lihang Yao
Mark R Bowlby
Pamela L Tannenbaum
Paul J Coleman
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P2888
P304
P356
10.1038/NPP.2013.139
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P577
2013-05-31T00:00:00Z
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P6179
1012216274