Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia - Test2 - elhamkhani - TriplyDB

Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia

Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia

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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators Neuroendocrine and sympathetic responses to an orexin receptor antagonist, SB-649868, and alprazolam following insulin-induced hypoglycemia in humans Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs.Evaluation of potential PET imaging probes for the orexin 2 receptors.Electroencephalographic power spectral density profile of the orexin receptor antagonist suvorexant in patients with primary insomnia and healthy subjects.Suvorexant for the treatment of insomnia.Enhanced slow-wave EEG activity and thermoregulatory impairment following the inhibition of the lateral hypothalamus in the rat.The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold.The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors.Quantitative electroencephalography within sleep/wake states differentiates GABAA modulators eszopiclone and zolpidem from dual orexin receptor antagonists in rats.Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators.Discovery and development of orexin receptor antagonists as therapeutics for insomnia.Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism.Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status.Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders.The behavioral pharmacology of zolpidem: evidence for the functional significance of α1-containing GABA(A) receptors.The hypocretin/orexin system: an increasingly important role in neuropsychiatry.Headache, drugs and sleep.Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease?Orexin OX2 Receptor Antagonists as Sleep Aids.Randomised clinical trial of the effects of prolonged-release melatonin, temazepam and zolpidem on slow-wave activity during sleep in healthy people.Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors.Distinct effects of IPSU and suvorexant on mouse sleep architecture.Dual Orexin Receptor Antagonist, Almorexant, in Elderly Patients With Primary Insomnia: A Randomized, Controlled Study.Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition.Update on emerging drugs for insomnia.Cognitive behavioral therapy for insomnia combined with eszopiclone for the treatment of sleep disorder patients transferred out of the intensive care unit: A single-centred retrospective observational study Orexin Receptor Antagonists

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Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia

http://www.wikidata.org/entity/Q28257245

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Orexin receptors: pharmacology and therapeutic opportunities

Noise-induced sleep maintenance insomnia: hypnotic and residual effects of zaleplon

Phase I studies on the safety, tolerability, pharmacokinetics and pharmacodynamics of SB-649868, a novel dual orexin receptor antagonist

Proposed supplements and amendments to 'A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects', the Rechtschaffen & Kales (1968) standard

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat.

Abnormal sleep/wake dynamics in orexin knockout mice

The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats.

Residual effects of zaleplon and zolpidem following middle of the night administration five hours to one hour before awakening.

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