Role of ubiquitin ligases and the proteasome in oncogenesis: novel targets for anticancer therapies.
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The cilia-regulated proteasome and its role in the development of ciliopathies and cancerFOXO transcription factors: key regulators of cellular quality controlRegulation of the proteasome by ATP: implications for ischemic myocardial injury and donor heart preservationP53 mutations in colorectal cancer - molecular pathogenesis and pharmacological reactivationTrial Watch: Proteasomal inhibitors for anticancer therapyA DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effectSeizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinasePhase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma.Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy.Cell division cycle 34 is highly expressed in hepatitis C virus-positive hepatocellular carcinoma with favorable phenotypes.Exploring the RING-catalyzed ubiquitin transfer mechanism by MD and QM/MM calculations.Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells.A generic cycling hypoxia-derived prognostic gene signature: application to breast cancer profiling.ATF3 functions as a novel tumor suppressor with prognostic significance in esophageal squamous cell carcinoma.Human RAD6 promotes G1-S transition and cell proliferation through upregulation of cyclin D1 expression.Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer.HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase βA Phase 2 study of bortezomib combined with either idarubicin/cytarabine or cytarabine/etoposide in children with relapsed, refractory or secondary acute myeloid leukemia: a report from the Children's Oncology GroupPeptide and small molecule inhibitors of HECT-type ubiquitin ligasesPeptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulationSCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer.Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligaseRoles of ubiquitination and SUMOylation on prostate cancer: mechanisms and clinical implications.Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer.Molecular pathways: turning proteasomal protein degradation into a unique treatment approach.DCAF4L2 promotes colorectal cancer invasion and metastasis via mediating degradation of NFκb negative regulator PPM1BEffects of carbon ion irradiation and X-ray irradiation on the ubiquitylated protein accumulation.Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cellsTargeting ubiquitination for cancer therapies.Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cellsMicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression.Deregulated expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma in mice.Polypyrimidine Tract-Binding Protein 1 promotes proliferation, migration and invasion in clear-cell renal cell carcinoma by regulating alternative splicing of PKMMDM2 is a potential therapeutic target and prognostic factor for ovarian clear cell carcinomas with wild type TP53.Regulation of stem cell function by protein ubiquitylationTranslational regulator eIF2α in tumor.Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein functionEpigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.Bisbibenzyls, novel proteasome inhibitors, suppress androgen receptor transcriptional activity and expression accompanied by activation of autophagy in prostate cancer LNCaP cells.The tumor suppressor SHIP1 colocalizes in nucleolar cavities with p53 and components of PML nuclear bodies.
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Role of ubiquitin ligases and the proteasome in oncogenesis: novel targets for anticancer therapies.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 28 January 2013
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Role of ubiquitin ligases and ...... gets for anticancer therapies.
@en
Role of ubiquitin ligases and ...... gets for anticancer therapies.
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type
label
Role of ubiquitin ligases and ...... gets for anticancer therapies.
@en
Role of ubiquitin ligases and ...... gets for anticancer therapies.
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prefLabel
Role of ubiquitin ligases and ...... gets for anticancer therapies.
@en
Role of ubiquitin ligases and ...... gets for anticancer therapies.
@nl
P2093
P2860
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P1476
Role of ubiquitin ligases and ...... gets for anticancer therapies.
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Gail S Eckhardt
John J Tentler
Lindsey N Micel
Peter G Smith
P2860
P304
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10.1200/JCO.2012.44.0958
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P577
2013-01-28T00:00:00Z