Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.
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Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human liversIdentification of a functional antioxidant response element within the eighth intron of the human ABCC3 geneRegulation of Nrf2-an updateNrf2 signaling and cell survivalCross-species gene expression analysis of species specific differences in the preclinical assessment of pharmaceutical compoundsNrf2:INrf2 (Keap1) signaling in oxidative stressXenobiotic, bile acid, and cholesterol transporters: function and regulation.Interaction of oxazaphosphorines with multidrug resistance-associated protein 4 (MRP4).Target organ specific activity of drosophila MRP (ABCC1) moderates developmental toxicity of methylmercuryEffect of caloric restriction and AMPK activation on hepatic nuclear receptor, biotransformation enzyme, and transporter expression in lean and obese mice.Aspirin influences megakaryocytic gene expression leading to up-regulation of multidrug resistance protein-4 in human platelets.Alteration of hepatic but not renal transporter expression in diet-induced obese mice3',4',5',5,7-pentamethoxyflavone sensitizes Cisplatin-resistant A549 cells to Cisplatin by inhibition of Nrf2 pathwayRegulation of hepatic ABCC transporters by xenobiotics and in disease states.Renal efflux transporter expression in pregnant mice with Type I diabetesCoordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice.Severe diabetes and leptin resistance cause differential hepatic and renal transporter expression in mice.Drug disposition alterations in liver disease: extrahepatic effects in cholestasis and nonalcoholic steatohepatitis.Alcohol cirrhosis alters nuclear receptor and drug transporter expression in human liver.Pregnancy represses induction of efflux transporters in livers of type I diabetic mice.LOSS of Mrp1 alters detoxification enzyme expression in a tissue- and hormonal-status-specific manner.Altered Hepatic Transport by Fetal Arsenite Exposure in Diet-Induced Fatty Liver Disease.Applications of genetically modified tools to safety assessment in drug developmentOleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice.Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress.Environmental chemicals as substrates, inhibitors or inducers of drug transporters: implication for toxicokinetics, toxicity and pharmacokinetics.The role of nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells.New insights in the biology of ABC transporters ABCC2 and ABCC3: impact on drug disposition.Estrogen potentiates reactive oxygen species (ROS) tolerance to initiate carcinogenesis and promote cancer malignant transformation.Altered Expression of Transporters, its Potential Mechanisms and Influences in the Liver of Rodent Models Associated with Diabetes Mellitus and Obesity.PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling.Multidrug Resistance Protein-4 Influences Aspirin Toxicity in Human Cell Line.Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance.Inhibition of IGF-IR increases chemosensitivity in human colorectal cancer cells through MRP-2 promoter suppression.Dual action of peroxisome proliferator-activated receptor alpha in perfluorodecanoic acid-induced hepatotoxicity.Bimodal role of Kupffer cells during colorectal cancer liver metastasisPPAR Medicines and Human Disease: The ABCs of It All.Colloidal carbon stimulation of Kupffer cells triggers Nrf2 activation in the isolated perfused rat liver.Kupffer cells suppress perfluorononanoic acid-induced hepatic peroxisome proliferator-activated receptor α expression by releasing cytokines.The renin angiotensin system regulates Kupffer cells in colorectal liver metastases.
P2860
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P2860
Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 29 August 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Nrf2- and PPAR alpha-mediated ...... id and perfluorodecanoic acid.
@en
Nrf2- and PPAR alpha-mediated ...... id and perfluorodecanoic acid.
@nl
type
label
Nrf2- and PPAR alpha-mediated ...... id and perfluorodecanoic acid.
@en
Nrf2- and PPAR alpha-mediated ...... id and perfluorodecanoic acid.
@nl
prefLabel
Nrf2- and PPAR alpha-mediated ...... id and perfluorodecanoic acid.
@en
Nrf2- and PPAR alpha-mediated ...... id and perfluorodecanoic acid.
@nl
P2093
P2860
P356
P1476
Nrf2- and PPAR alpha-mediated ...... cid and perfluorodecanoic acid
@en
P2093
Curtis D Klaassen
Jonathan M Maher
Jose E Manautou
Matthew Z Dieter
Yuji Tanaka
P2860
P304
P356
10.1093/TOXSCI/KFN177
P577
2008-08-29T00:00:00Z