The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain.
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Biology of adeno-associated viral vectors in the central nervous systemA new look at cerebrospinal fluid circulationA paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.Aβ Clearance, "hub" of Multiple Deficiencies Leading to Alzheimer DiseaseGene-based therapy of Parkinson's Disease: Translation from animal model to human clinical trial employing convection enhanced deliveryInteraction between therapeutic interventions for Alzheimer's disease and physiological Aβ clearance mechanismsCytoplasmic electric fields and electroosmosis: possible solution for the paradoxes of the intracellular transport of biomoleculesAxonal transport of AAV9 in nonhuman primate brain.The Glymphatic System: A Beginner's GuideMRI-based computational model of heterogeneous tracer transport following local infusion into a mouse hind limb tumorA new brain drug delivery strategy: focused ultrasound-enhanced intranasal drug deliveryFocused ultrasound-enhanced intranasal brain delivery of brain-derived neurotrophic factor.Trafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routes.Gene transfer corrects acute GM2 gangliosidosis--potential therapeutic contribution of perivascular enzyme flowUltra-fast magnetic resonance encephalography of physiological brain activity - Glymphatic pulsation mechanisms?Image-guided convection-enhanced delivery platform in the treatment of neurological diseases.Future applications: gene therapy.AAV provides an alternative for gene therapy of the peripheral sensory nervous system.Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primatesConvection Enhanced Delivery: A Comparison of infusion characteristics in ex vivo and in vivo non-human primate brain tissueAnatomical differences determine distribution of adenovirus after convection-enhanced delivery to the rat brain.Guided delivery of adeno-associated viral vectors into the primate brainImaging of cells and nanoparticles: implications for drug delivery to the brain.Formulations for Intranasal Delivery of Pharmacological Agents to Combat Brain Disease: A New Opportunity to Tackle GBM?Delayed intranasal delivery of hypoxic-preconditioned bone marrow mesenchymal stem cells enhanced cell homing and therapeutic benefits after ischemic stroke in mice.Impairment of paravascular clearance pathways in the aging brain.Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice.Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence.Predictive models for pressure-driven fluid infusions into brain parenchyma.Real-time imaging of perivascular transport of nanoparticles during convection-enhanced delivery in the rat cortex.Methodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease.Merits of combination cortical, subcortical, and cerebellar injections for the treatment of Niemann-Pick disease type AEvaluation of pressure-driven brain infusions in nonhuman primates by intra-operative 7 Tesla MRI.Intranasal insulin protects against substantia nigra dopaminergic neuronal loss and alleviates motor deficits induced by 6-OHDA in ratsSafety of real-time convection-enhanced delivery of liposomes to primate brain: a long-term retrospective.Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primates.Nonviral approaches for neuronal delivery of nucleic acids.Gene therapy for misfolding protein diseases of the central nervous system.Pathways of infusate loss during convection-enhanced delivery into the putamen nucleusWidespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease.
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The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 02 May 2006
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vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The "perivascular pump" driven ...... ic molecules within the brain.
@en
The "perivascular pump" driven ...... ic molecules within the brain.
@nl
type
label
The "perivascular pump" driven ...... ic molecules within the brain.
@en
The "perivascular pump" driven ...... ic molecules within the brain.
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prefLabel
The "perivascular pump" driven ...... ic molecules within the brain.
@en
The "perivascular pump" driven ...... ic molecules within the brain.
@nl
P2093
P2860
P1433
P1476
The "perivascular pump" driven ...... ic molecules within the brain.
@en
P2093
Charles Noble
Hanna Mirek
John W Park
Krystof Bankiewicz
Laszlo Tamas
Martha C Bohn
Piotr Hadaczek
Yoji Yamashita
P2860
P356
10.1016/J.YMTHE.2006.02.018
P577
2006-05-02T00:00:00Z