Cholinergic system during the progression of Alzheimer's disease: therapeutic implications. - Test2 - elhamkhani - TriplyDB

Cholinergic system during the progression of Alzheimer's disease: therapeutic implications.

Cholinergic system during the progression of Alzheimer's disease: therapeutic implications.

http://www.wikidata.org/entity/Q37318152

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Novel small molecule activators of the Trk family of receptor tyrosine kinases Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity Mild cognitive impairment: pathology and mechanisms.Potential drug-drug interactions in Alzheimer patients with behavioral symptoms Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research Nicotinic ACh receptors as therapeutic targets in CNS disorders Cognitive Slowing in Gulf War Illness Predicts Executive Network Hyperconnectivity: Study in a Population-Representative Sample Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function.Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.Increased matrix metalloproteinase 9 activity in mild cognitive impairment.Acteoside and Isoacteoside Protect Amyloid β Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo.Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression.Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease.Protective Effects of Wogonin against Alzheimer's Disease by Inhibition of Amyloidogenic Pathway.The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer's Disease Neuropathology BMP9 protects septal neurons from axotomy-evoked loss of cholinergic phenotype Sympathetic sprouting in visual cortex stimulated by cholinergic denervation rescues expression of two forms of long-term depression at layer 2/3 synapses.Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease BMP9 (bone morphogenetic protein 9) induces NGF as an autocrine/paracrine cholinergic trophic factor in developing basal forebrain neurons.A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.Alteration in cellular acetylcholine influences dauer formation in Caenorhabditis elegans Intranasal "painless" human Nerve Growth Factor [corrected] slows amyloid neurodegeneration and prevents memory deficits in App X PS1 mice Evaluation of a combined therapeutic regimen of 8-OH-DPAT and environmental enrichment after experimental traumatic brain injury.Chronic cerebral ischaemia forms new cholinergic mechanisms of learning and memory.Cholinotrophic basal forebrain system alterations in 3xTg-AD transgenic mice.Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice.Immunolesion-induced loss of cholinergic projection neurones promotes β-amyloidosis and tau hyperphosphorylation in the hippocampus of triple-transgenic mice.Biologic and plastic effects of experimental traumatic brain injury treatment paradigms and their relevance to clinical rehabilitation.IGF2 ameliorates amyloidosis, increases cholinergic marker expression and raises BMP9 and neurotrophin levels in the hippocampus of the APPswePS1dE9 Alzheimer's disease model mice.Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons.Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.Immunization Against Specific Fragments of Neurotrophin p75 Receptor Protects Forebrain Cholinergic Neurons in the Olfactory Bulbectomized Mice Association of Pancreatic Polypeptide with Mild Cognitive Impairment Varies by APOE ε4 Allele.Structure-activity relationship studies of benzyl-, phenethyl-, and pyridyl-substituted tetrahydroacridin-9-amines as multitargeting agents to treat Alzheimer's disease.Hippocampal plasticity during the progression of Alzheimer's disease.TrkA gene ablation in basal forebrain results in dysfunction of the cholinergic circuitry.Intraperitoneal Administration of a Novel TAT-BDNF Peptide Ameliorates Cognitive Impairments via Modulating Multiple Pathways in Two Alzheimer's Rodent Models.

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Cholinergic system during the progression of Alzheimer's disease: therapeutic implications.

http://www.wikidata.org/entity/Q37318152

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Cholinergic system during the ...... ase: therapeutic implications.

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Cholinergic system during the ...... ase: therapeutic implications.

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Cholinergic system during the ...... ase: therapeutic implications.

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Cholinergic system during the ...... ase: therapeutic implications.

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Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders

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Cholinergic system during the ...... ase: therapeutic implications.

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Elliott J Mufson

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Scott E Counts

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Stephen D Ginsberg

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Sylvia E Perez

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P2860

beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain

Sortilin is essential for proNGF-induced neuronal cell death

Galanin in Alzheimer's disease: neuroinhibitory or neuroprotective?

Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death

Neurotrophin signal transduction in the nervous system.

Nerve growth factor signaling, neuroprotection, and neural repair.

Regulation of cell survival by secreted proneurotrophins.

Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

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11

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Alzheimer's disease

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2631573

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