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Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificityStructural basis for fibroblast growth factor receptor 2 activation in Apert syndromeStructural basis by which alternative splicing confers specificity in fibroblast growth factor receptorsStructural basis by which alternative splicing modulates the organizer activity of FGF8 in the brainInsights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuityFibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFsIdentification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transductionDecreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and miceTissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerizationSignal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomesThe alternatively spliced acid box region plays a key role in FGF receptor autoinhibitionFGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation responseDigenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadismReceptor specificity of the fibroblast growth factor family. The complete mammalian FGF familyBetaKlotho is required for metabolic activity of fibroblast growth factor 21Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily membersImpaired FGF signaling contributes to cleft lip and palateExploring mechanisms of FGF signalling through the lens of structural biologyCrystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibitionHomodimerization Controls the Fibroblast Growth Factor 9 Subfamily's Receptor Binding and Heparan Sulfate-Dependent Diffusion in the Extracellular MatrixA Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine KinasesA crystallographic snapshot of tyrosine trans-phosphorylation in actionCrystal Structure of a Fibroblast Growth Factor Homologous Factor (FHF) Defines a Conserved Surface on FHFs for Binding and Modulation of Voltage-gated Sodium ChannelsPlasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function MutationsStructural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 MutationEndocrinization of FGF1 produces a neomorphic and potent insulin sensitizerPoint mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cellsFGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosisMolecular mechanisms of fibroblast growth factor signaling in physiology and pathologyUnderstanding the molecular basis of Apert syndromeRegulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4FGF23 promotes renal calcium reabsorption through the TRPV5 channelThe parathyroid is a target organ for FGF23 in ratsEndocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.Identification of phosphopeptides by MALDI Q-TOF MS in positive and negative ion modes after methyl esterification.Compositional analysis of heparin/heparan sulfate interacting with fibroblast growth factor.fibroblast growth factor receptor complexesIsolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation.
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Moosa Mohammadi
@ast
Moosa Mohammadi
@en
Moosa Mohammadi
@es
Moosa Mohammadi
@nl
Moosa Mohammadi
@sl
type
label
Moosa Mohammadi
@ast
Moosa Mohammadi
@en
Moosa Mohammadi
@es
Moosa Mohammadi
@nl
Moosa Mohammadi
@sl
prefLabel
Moosa Mohammadi
@ast
Moosa Mohammadi
@en
Moosa Mohammadi
@es
Moosa Mohammadi
@nl
Moosa Mohammadi
@sl
P106
P31
P496
0000-0003-2434-9437
P569
2000-01-01T00:00:00Z