Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21 - Test2 - elhamkhani - TriplyDB

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

http://www.wikidata.org/entity/Q24318639

about

Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1 betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors FGF21 N- and C-termini play different roles in receptor interaction and activation Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis Obesity is a fibroblast growth factor 21 (FGF21)-resistant state Endocrine fibroblast growth factors 15/19 and 21: from feast to famine Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response Klotho and aging Fibroblast growth factor 21: from pharmacology to physiology Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk FGF21 and Cardiac Physiopathology Inventing new medicines: The FGF21 story Miscellaneous non-inflammatory musculoskeletal conditions. Hyperphosphatemic familial tumoral calcinosis (FGF23, GALNT3 and αKlotho)Regulation and function of the FGF23/klotho endocrine pathways Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers Fibroblast growth factor signaling in the vasculature Exploring mechanisms of FGF signalling through the lens of structural biology Transcriptional regulation of fibroblast growth factor 21 expression Downstream signaling pathways in mouse adipose tissues following acute in vivo administration of fibroblast growth factor 21 Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor FGF21 promotes metabolic homeostasis via white adipose and leptin in mice Klotho and phosphate are modulators of pathologic uremic cardiac remodeling.Fibroblast Growth Factor 21 Analogs for Treating Metabolic Disorders.Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state Farnesoid X receptor: a master regulator of hepatic triglyceride and glucose homeostasis Fibroblast growth factors as tissue repair and regeneration therapeutics.Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology A better anti-diabetic recombinant human fibroblast growth factor 21 (rhFGF21) modified with polyethylene glycol FGF21 requires βklotho to act in vivo Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes Fundamentals of FGF19 & FGF21 action in vitro and in vivo Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways

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Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

http://www.wikidata.org/entity/Q24318639

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2007 nî lūn-bûn

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2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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Journal of Biological Chemistry

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Addie S Dickson

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Anna V Eliseenkova

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Hiroshi Kurosu

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Kevin P Rosenblatt

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Makoto Kuro-o

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Mihwa Choi

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Steven A Kliewer

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P2860

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

Receptor specificity of the fibroblast growth factor family

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

FGF-21 as a novel metabolic regulator.

Suppression of aging in mice by the hormone Klotho

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family

BetaKlotho is required for metabolic activity of fibroblast growth factor 21

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

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26687-26695

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1768660

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10.1074/JBC.M704165200

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37

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282

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Moosa Mohammadi

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2007-07-10T00:00:00Z

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6213865

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17623664

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positive regulation of ERK1 and ERK2 cascade

Fibroblast growth factor receptor 4

Fibroblast growth factor 19

Fibroblast growth factor 21

P932

2496965

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