The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation.
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Functional Role of G9a Histone Methyltransferase in CancerAlterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical ImplicationsG9a Inhibition Induces Autophagic Cell Death via AMPK/mTOR Pathway in Bladder Transitional Cell CarcinomaKDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid MetabolismOne-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy.Brain-derived neurotrophic factor involved epigenetic repression of UGT2B7 in colorectal carcinoma: A mechanism to alter morphine glucuronidation in tumor.G9A promotes tumor cell growth and invasion by silencing CASP1 in non-small-cell lung cancer cells.Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma.Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism.SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis.EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cellscMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation.Functional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinomaSerine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells.Role of several histone lysine methyltransferases in tumor development.The importance of serine metabolism in cancerG9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation.DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge.Recently discovered EZH2 and EHMT2 (G9a) inhibitors.Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis.Computational prediction of methylation types of covalently modified lysine and arginine residues in proteins.A chemical probe toolbox for dissecting the cancer epigenome.G9a histone methyltransferase inhibitor BIX01294 promotes expansion of adult cardiac progenitor cells without changing their phenotype or differentiation potential.Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells.Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors†Electronic supplementary information (ESI) available. See DOI: 10.1039/c4md00274a.A systems medicine approach for finding target proteins affecting treatment outcomes in patients with non-Hodgkin lymphoma.Methyltransferase G9a promotes cervical cancer angiogenesis and decreases patient survival.Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cellsYAP/TAZ-mediated activation of serine metabolism and methylation regulation is critical for LKB1-deficient breast cancer progression.Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway.EZH2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissection.Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase.BIX-01294 sensitizes renal cancer Caki cells to TRAIL-induced apoptosis through downregulation of survivin expression and upregulation of DR5 expression.Reciprocal Regulation of Metabolic Reprogramming and Epigenetic Modifications in CancerThe Methylation Status of the Epigenome: Its Emerging Role in the Regulation of Tumor Angiogenesis and Tumor Growth, and Potential for Drug TargetingPre-treatment or Post-treatment of Human Glioma Cells With BIX01294, the Inhibitor of Histone Methyltransferase G9a, Sensitizes Cells to Temozolomide
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The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The histone H3 methyltransfera ...... ll survival and proliferation.
@en
The histone H3 methyltransfera ...... ll survival and proliferation.
@nl
type
label
The histone H3 methyltransfera ...... ll survival and proliferation.
@en
The histone H3 methyltransfera ...... ll survival and proliferation.
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prefLabel
The histone H3 methyltransfera ...... ll survival and proliferation.
@en
The histone H3 methyltransfera ...... ll survival and proliferation.
@nl
P2093
P2860
P1433
P1476
The histone H3 methyltransfera ...... ll survival and proliferation.
@en
P2093
Han-Fei Ding
Hongjuan Cui
Jeong-Hyeon Choi
John M Asara
Liqun Yang
Shuang Huang
Xiangwei Wang
P2860
P304
P356
10.1016/J.CMET.2013.11.004
P577
2013-12-01T00:00:00Z