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The other side of the coin: the tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND-CDK4/6-RB axisSix plant extracts delay yeast chronological aging through different signaling pathwaysLong term exposure to L-arginine accelerates endothelial cell senescence through arginase-II and S6K1 signalingFrom rapalogs to anti-aging formula.Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell.Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition.Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice.Rejuvenating immunity: "anti-aging drug today" eight years later.Koschei the immortal and anti-aging drugsDual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).Accelerated geroncogenesis in hereditary breast-ovarian cancer syndromePreclinical validation of a novel compound targeting p70S6 kinase in breast cancer.CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion.Gerosuppression by pan-mTOR inhibitors.ZRF1 is a novel S6 kinase substrate that drives the senescence programme.Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells.
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 09 September 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
S6K in geroconversion.
@en
S6K in geroconversion.
@nl
type
label
S6K in geroconversion.
@en
S6K in geroconversion.
@nl
prefLabel
S6K in geroconversion.
@en
S6K in geroconversion.
@nl
P2860
P356
P1433
P1476
S6K in geroconversion.
@en
P2093
Olga V Leontieva
Zoya N Demidenko
P2860
P304
P356
10.4161/CC.26248
P577
2013-09-09T00:00:00Z