Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation.
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Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced ActivityHead-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregationSpiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocationEngineering enhanced protein disaggregases for neurodegenerative diseaseSuramin inhibits Hsp104 ATPase and disaggregase activityThe Hsp104 N-terminal domain enables disaggregase plasticity and potentiationMolecular chaperones are nanomachines that catalytically unfold misfolded and alternatively folded proteins.Interplay between E. coli DnaK, ClpB and GrpE during protein disaggregation.Mechanistic Insights into Hsp104 Potentiation.Adenosine diphosphate restricts the protein remodeling activity of the Hsp104 chaperone to Hsp70 assisted disaggregationMechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104.Heat Shock Proteins in Dermatophytes: Current Advances and PerspectivesRepurposing Hsp104 to Antagonize Seminal Amyloid and Counter HIV Infection.Comparative Analysis of the Structure and Function of AAA+ Motors ClpA, ClpB, and Hsp104: Common Threads and Disparate Functions.Disparate Mutations Confer Therapeutic Gain of Hsp104 Function.The metazoan protein disaggregase and amyloid depolymerase system: Hsp110, Hsp70, Hsp40, and small heat shock proteins.Activation of the DnaK-ClpB Complex is Regulated by the Properties of the Bound Substrate.
P2860
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P2860
Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation.
description
2013 nî lūn-bûn
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年學術文章
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name
Conserved distal loop residues ...... endent protein disaggregation.
@en
Conserved distal loop residues ...... endent protein disaggregation.
@nl
type
label
Conserved distal loop residues ...... endent protein disaggregation.
@en
Conserved distal loop residues ...... endent protein disaggregation.
@nl
prefLabel
Conserved distal loop residues ...... endent protein disaggregation.
@en
Conserved distal loop residues ...... endent protein disaggregation.
@nl
P2093
P2860
P356
P1476
Conserved distal loop residues ...... pendent protein disaggregation
@en
P2093
David Snead
Elizabeth A Sweeny
Eunice H Leung
Kushol Gupta
Michelle S Go
Morgan E Desantis
Petra Wendler
P2860
P304
P356
10.1074/JBC.M113.520759
P407
P577
2013-11-26T00:00:00Z