Engineering enhanced protein disaggregases for neurodegenerative disease
about
Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced ActivityPrion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative diseaseChaperones in NeurodegenerationHuman cyclophilin 40 unravels neurotoxic amyloids.Mechanistic Insights into Hsp104 Potentiation.Engineering therapeutic protein disaggregases.Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104.Repurposing Hsp104 to Antagonize Seminal Amyloid and Counter HIV Infection.Crystal structures of Hsp104 N-terminal domains from Saccharomyces cerevisiae and Candida albicans suggest the mechanism for the function of Hsp104 in dissolving prions.Role of FET proteins in neurodegenerative disorders.Expanding role of molecular chaperones in regulating α-synuclein misfolding; implications in Parkinson's disease.Prions, Chaperones, and Proteostasis in Yeast.Designer protein disaggregases to counter neurodegenerative disease.Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease.Yeast proteinopathy models: a robust tool for deciphering the basis of neurodegeneration.RNA-binding proteins with prion-like domains in health and disease.It's Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles.The Neuroprotective Role of Protein Quality Control in Halting the Development of Alpha-Synuclein Pathology.Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.Disparate Mutations Confer Therapeutic Gain of Hsp104 Function.Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies.Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches
P2860
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P2860
Engineering enhanced protein disaggregases for neurodegenerative disease
description
2015 nî lūn-bûn
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2015 թուականին հրատարակուած գիտական յօդուած
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2015 թվականին հրատարակված գիտական հոդված
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年论文
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name
Engineering enhanced protein disaggregases for neurodegenerative disease
@ast
Engineering enhanced protein disaggregases for neurodegenerative disease
@en
Engineering enhanced protein disaggregases for neurodegenerative disease
@nl
type
label
Engineering enhanced protein disaggregases for neurodegenerative disease
@ast
Engineering enhanced protein disaggregases for neurodegenerative disease
@en
Engineering enhanced protein disaggregases for neurodegenerative disease
@nl
prefLabel
Engineering enhanced protein disaggregases for neurodegenerative disease
@ast
Engineering enhanced protein disaggregases for neurodegenerative disease
@en
Engineering enhanced protein disaggregases for neurodegenerative disease
@nl
P2860
P921
P3181
P1433
P1476
Engineering enhanced protein disaggregases for neurodegenerative disease
@en
P2093
James Shorter
Meredith E Jackrel
P2860
P304
P3181
P356
10.1080/19336896.2015.1020277
P407
P5008
P577
2015-01-01T00:00:00Z