Critical role for hypothalamic mTOR activity in energy balance. - Test2 - elhamkhani - TriplyDB

Critical role for hypothalamic mTOR activity in energy balance.

Critical role for hypothalamic mTOR activity in energy balance.

http://www.wikidata.org/entity/Q37465429

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An emerging role for TOR signaling in mammalian tissue and stem cell physiology Recent advances in understanding leptin signaling and leptin resistance The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance The neurology of mTOR A possible link between BDNF and mTOR in control of food intake Brain regulation of energy balance and body weight.Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells Impaired hypothalamic mTOR activation in the adult rat offspring born to mothers fed a low-protein diet Obesity-associated variants within FTO form long-range functional connections with IRX3 mTOR signaling in tumorigenesis Excessive Leucine-mTORC1-Signalling of Cow Milk-Based Infant Formula: The Missing Link to Understand Early Childhood Obesity Modulation of food intake by mTOR signalling in the dorsal motor nucleus of the vagus in male rats: focus on ghrelin and nesfatin-1 Phospholipases D1 and D2 Suppress Appetite and Protect against Overweight Postnatal growth after intrauterine growth restriction alters central leptin signal and energy homeostasis.Insulin and glucagon regulate pancreatic α-cell proliferation LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo.Characterization of mice expressing Ins1 gene promoter driven CreERT recombinase for conditional gene deletion in pancreatic β-cells.5-HT obesity medication efficacy via POMC activation is maintained during aging Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring.Regulation of gastric hormones by systemic rapamycin.KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation.DEP domain-containing mTOR-interacting protein in the rat brain: distribution of expression and potential implication.Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin.Higher branched-chain amino acid intake is associated with a lower prevalence of being overweight or obese in middle-aged East Asian and Western adults.Glucocorticoids attenuate the central sympathoexcitatory actions of insulin.RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis.Melanocortin control of energy balance: evidence from rodent models.Leucine deprivation stimulates fat loss via increasing CRH expression in the hypothalamus and activating the sympathetic nervous system Validation of the rat model of cryptogenic infantile spasms.Hypothalamic inflammation: a double-edged sword to nutritional diseases.Gastric mammalian target of rapamycin signaling, hormone production and energy metabolism.AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase.Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway.mTORC1 signaling and regulation of pancreatic β-cell mass.Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition.S6K1 in the central nervous system regulates energy expenditure via MC4R/CRH pathways in response to deprivation of an essential amino acid.Rapamycin has age-, treatment paradigm-, and model-specific anticonvulsant effects and modulates neuropeptide Y expression in rats.Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis Knockin of Cre Gene at Ins2 Locus Reveals No Cre Activity in Mouse Hypothalamic Neurons.Leptin signaling and circuits in puberty and fertility

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Critical role for hypothalamic mTOR activity in energy balance.

http://www.wikidata.org/entity/Q37465429

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on April 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Critical role for hypothalamic mTOR activity in energy balance.

@en

Critical role for hypothalamic mTOR activity in energy balance.

@nl

type

label

Critical role for hypothalamic mTOR activity in energy balance.

@en

Critical role for hypothalamic mTOR activity in energy balance.

@nl

prefLabel

Critical role for hypothalamic mTOR activity in energy balance.

@en

Critical role for hypothalamic mTOR activity in energy balance.

@nl

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J.CMET.2009.03.005

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Cell Metabolism

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Critical role for hypothalamic mTOR activity in energy balance.

@en

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Darren Opland

http://www.w3.org/2001/XMLSchema#string

David Kwiatkowski

http://www.w3.org/2001/XMLSchema#string

Eneida C Villanueva

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Heike Münzberg

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Hiroyuki Mori

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Ken Inoki

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Kun-Liang Guan

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Martin G Myers

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Miro Faouzi

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Tsuneo Ikenoue

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Direct control of the Forkhead transcription factor AFX by protein kinase B

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

TOR signaling in growth and metabolism

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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362-374

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scholarly article

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10.1016/J.CMET.2009.03.005

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4

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9

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Ormond Macdougald

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2009-04-01T00:00:00Z

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24266887

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19356717

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2790375

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