Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line. - Test2 - elhamkhani - TriplyDB

Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line.

Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line.

http://www.wikidata.org/entity/Q37467545

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Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells Plasma membrane potential oscillations in insulin secreting Ins-1 832/13 cells do not require glycolysis and are not initiated by fluctuations in mitochondrial bioenergetics.Regulation of insulin secretion: role of mitochondrial signalling.ß-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.A role for cytosolic isocitrate dehydrogenase as a negative regulator of glucose signaling for insulin secretion in pancreatic ß-cells.Mitochondrial malic enzyme 3 is important for insulin secretion in pancreatic β-cells Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION In vivo, cardiac-specific knockdown of a target protein, malic enzyme-1, in rat via adenoviral delivery of DNA for non-native miRNA.Repressing malic enzyme 1 redirects glucose metabolism, unbalances the redox state, and attenuates migratory and invasive abilities in nasopharyngeal carcinoma cell lines.Overcoming the spatial barriers of the stimulus secretion cascade in pancreatic β-cells.Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion.The Pancreatic β-Cell: A Bioenergetic Perspective.Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion.Fuel-Stimulated Insulin Secretion Depends upon Mitochondria Activation and the Integration of Mitochondrial and Cytosolic Substrate Cycles Metabolomic analysis of pancreatic β-cell insulin release in response to glucose.Aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor-1{beta} plays a critical role in maintaining glucose-stimulated anaplerosis and insulin release from pancreatic {beta}-cells.

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Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line.

http://www.wikidata.org/entity/Q37467545

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on December 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Chronic reduction of the cytosolic or mitochondrial NAD

@nl

Chronic reduction of the cytos ...... in a rat insulinoma cell line.

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type

label

Chronic reduction of the cytosolic or mitochondrial NAD

@nl

Chronic reduction of the cytos ...... in a rat insulinoma cell line.

@en

prefLabel

Chronic reduction of the cytosolic or mitochondrial NAD

@nl

Chronic reduction of the cytos ...... in a rat insulinoma cell line.

@en

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JBC.M109.040394

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Journal of Biological Chemistry

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Chronic reduction of the cytos ...... in a rat insulinoma cell line.

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Laura J Brown

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Melissa J Longacre

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Michael J Macdonald

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Mindy A Kendrick

http://www.w3.org/2001/XMLSchema#string

Noaman M Hasan

http://www.w3.org/2001/XMLSchema#string

Scott W Stoker

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P2860

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells

Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets

Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shunt

miR-375 maintains normal pancreatic alpha- and beta-cell mass

Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectors

A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion

A pancreatic islet-specific microRNA regulates insulin secretion

Feasibility of pathways for transfer of acyl groups from mitochondria to the cytosol to form short chain acyl-CoAs in the pancreatic beta cell

MicroRNA expression is required for pancreatic islet cell genesis in the mouse

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35359-35367

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scholarly article

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10.1074/JBC.M109.040394

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51

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284

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2009-12-01T00:00:00Z

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19858194

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P932

2790965

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