The human sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone (OKN-007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1 signaling

The human sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone (OKN-007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1 signaling

Item
http://www.wikidata.org/entity/Q37467900
Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advancesDesign and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases.Activation of the transforming growth factor-β/SMAD transcriptional pathway underlies a novel tumor-promoting role of sulfatase 1 in hepatocellular carcinoma.Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts.Custom RT-qPCR-array for glaucoma filtering surgery prognosis.Role of heparan sulfatases in ovarian and breast cancer.Histone acetyltransferase PCAF up-regulated cell apoptosis in hepatocellular carcinoma via acetylating histone H4 and inactivating AKT signaling.SOX9: a stem cell transcriptional regulator of secreted niche signaling factors.Post-Synthetic Regulation of HS Structure: The Yin and Yang of the Sulfs in Cancer.The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics.Targeting multiple oncogenic pathways for the treatment of hepatocellular carcinoma.Epigenetic Regulation of the Biosynthesis & Enzymatic Modification of Heparan Sulfate Proteoglycans: Implications for Tumorigenesis and Cancer Biomarkers.New tumor suppressor microRNAs target glypican-3 in human liver cancer.EDG2 enhanced the progression of hepatocellular carcinoma by LPA/PI3K/AKT/ mTOR signaling.Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression
P2860

The human sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone (OKN-007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1 signaling

Item
http://www.wikidata.org/entity/Q37467900
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 29 October 2012
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The human sulfatase 2 inhibito ...... D2 and Hedgehog/GLI1 signaling
@en
The human sulfatase 2 inhibito ...... 2 and Hedgehog/GLI1 signaling.
@nl
type
label
The human sulfatase 2 inhibito ...... D2 and Hedgehog/GLI1 signaling
@en
The human sulfatase 2 inhibito ...... 2 and Hedgehog/GLI1 signaling.
@nl
prefLabel
The human sulfatase 2 inhibito ...... D2 and Hedgehog/GLI1 signaling
@en
The human sulfatase 2 inhibito ...... 2 and Hedgehog/GLI1 signaling.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P932
P356
P1433
P1476
The human sulfatase 2 inhibito ...... D2 and Hedgehog/GLI1 signaling
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P932