JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism. - Test2 - elhamkhani - TriplyDB

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.

JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.

http://www.wikidata.org/entity/Q37475261

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Pyruvate Kinase M2: A Potential Target for Regulating Inflammation Pyruvate kinase M2 at a glance Adipose tissue dysfunction and its effects on tumor metabolism JMJD5 (Jumonji Domain-containing 5) Associates with Spindle Microtubules and Is Required for Proper Mitosis.PKM2: the thread linking energy metabolism reprogramming with epigenetics in cancer L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2 Activators of PKM2 in cancer metabolism.A novel pyruvate kinase M2 activator compound that suppresses lung cancer cell viability under hypoxia Isoform switch of pyruvate kinase M1 indeed occurs but not to pyruvate kinase M2 in human tumorigenesis.Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation.JMJD5 is a potential oncogene for colon carcinogenesis.Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome Phage display library selection of a hypoxia-binding scFv antibody for liver cancer metabolic marker discovery.Warburg-like Glycolysis and Lactate Shuttle in Mouse Decidua during Early Pregnancy ERK2-Pyruvate Kinase Axis Permits Phorbol 12-Myristate 13-Acetate-induced Megakaryocyte Differentiation in K562 Cells IGF1 regulates PKM2 function through Akt phosphorylation High Expression of Pyruvate Kinase M2 is Associated with Chemosensitivity to Epirubicin and 5-Fluorouracil in Breast Cancer.Overexpression of pyruvate kinase M2 associates with aggressive clinicopathological features and unfavorable prognosis in oral squamous cell carcinoma.Overexpression of histone demethylase JMJD5 promotes metastasis and indicates a poor prognosis in breast cancer.JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity.Population transcriptomes reveal synergistic responses of DNA polymorphism and RNA expression to extreme environments on the Qinghai-Tibetan Plateau in a predatory bird.Regulation of cell proliferation by hypoxia-inducible factors miR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer.PKM2 and cancer: The function of PKM2 beyond glycolysis.Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A 686.Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer.Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma.Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability.Cancer-like metabolism of the mammalian retina.Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions Pyruvate kinase M2 interacts with mammalian sterile 20-like kinase 1 and inhibits tamoxifen-induced apoptosis in human breast cancer cells.Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells.Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.GRIM-19: A master regulator of cytokine induced tumor suppression, metastasis and energy metabolism.PKM2, cancer metabolism, and the road ahead.GLUT3 and PKM2 regulate OCT4 expression and support the hypoxic culture of human embryonic stem cells.Non-Metabolic Role of PKM2 in Regulation of the HIV-1 LTR.Depletion of JMJD5 sensitizes tumor cells to microtubule-destabilizing agents by altering microtubule stability.

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JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.

http://www.wikidata.org/entity/Q37475261

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 16 December 2013

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

JMJD5 regulates PKM2 nuclear t ...... α-mediated glucose metabolism.

@en

JMJD5 regulates PKM2 nuclear t ...... α-mediated glucose metabolism.

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type

label

JMJD5 regulates PKM2 nuclear t ...... α-mediated glucose metabolism.

@en

JMJD5 regulates PKM2 nuclear t ...... α-mediated glucose metabolism.

@nl

prefLabel

JMJD5 regulates PKM2 nuclear t ...... α-mediated glucose metabolism.

@en

JMJD5 regulates PKM2 nuclear t ...... α-mediated glucose metabolism.

@nl

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PNAS.1311249111

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Proceedings of the National Academy of Sciences of the United States of America

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JMJD5 regulates PKM2 nuclear t ...... 1α-mediated glucose metabolism

@en

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Chun-Pu Lin

http://www.w3.org/2001/XMLSchema#string

Chung-Ching Chen

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Hsing-Jien Kung

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Hung-Jung Wang

http://www.w3.org/2001/XMLSchema#string

Jau-Song Yu

http://www.w3.org/2001/XMLSchema#string

So-Fang Yang

http://www.w3.org/2001/XMLSchema#string

Wen-Chi Cheng

http://www.w3.org/2001/XMLSchema#string

Wen-Ching Wang

http://www.w3.org/2001/XMLSchema#string

Yu-shan Lin

http://www.w3.org/2001/XMLSchema#string

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Immunoaffinity profiling of tyrosine phosphorylation in cancer cells

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription

KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

Regulation of cancer cell metabolism

Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

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279-284

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scholarly article

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10.1073/PNAS.1311249111

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1

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111

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Yoshihiro Izumiya

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2013-12-16T00:00:00Z

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259350685

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24344305

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