Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
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Disease-modifying therapeutic directions for Lewy-Body dementiasPropagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA.Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice.Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.Transmission of Soluble and Insoluble α-Synuclein to Mice.Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein.Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's diseaseAmyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice.Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice.Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.Strain-specific Fibril Propagation by an Aβ Dodecamer.Neuropathological Staging of Brain Pathology in Sporadic Parkinson's disease: Separating the Wheat from the Chaff.Potential of Cellular and Animal Models Based on a Prion-Like Propagation of α-Synuclein for Assessing Antiparkinson Agents.Neuropathology of multiple system atrophy: new thoughts about pathogenesis.Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like PropagationMechanisms of alpha-synuclein action on neurotransmission: cell-autonomous and non-cell autonomous roleAlpha-synuclein propagation: New insights from animal models.Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein.Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers.Exosomes in the Pathology of Neurodegenerative Diseases.Potential Modes of Intercellular α-Synuclein Transmission.Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice.α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.In vitro aggregation assays for the characterization of α-synuclein prion-like properties.Exogenous Alpha-Synuclein Alters Pre- and Post-Synaptic Activity by Fragmenting Lipid Rafts.Exocytosis and Spreading of Normal and Aberrant α-Synuclein.Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.Prying into the Prion Hypothesis for Parkinson's Disease.'Prion-like' propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum.Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology.Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils.
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Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 17 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Induction of CNS α-synuclein p ...... ogenic recombinant α-synuclein
@en
Induction of CNS α-synuclein p ...... genic recombinant α-synuclein.
@nl
type
label
Induction of CNS α-synuclein p ...... ogenic recombinant α-synuclein
@en
Induction of CNS α-synuclein p ...... genic recombinant α-synuclein.
@nl
prefLabel
Induction of CNS α-synuclein p ...... ogenic recombinant α-synuclein
@en
Induction of CNS α-synuclein p ...... genic recombinant α-synuclein.
@nl
P2093
P2860
P356
P1476
Induction of CNS α-synuclein p ...... ogenic recombinant α-synuclein
@en
P2093
Alex B McKinney
Amanda N Sacino
Benoit I Giasson
Michael A Thomas
Mieu Brooks
Nicholas H McGarvey
Todd E Golde
Yona Levites
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P2888
P356
10.1186/2051-5960-1-38
P577
2013-07-17T00:00:00Z
P5875
P6179
1020307649