HIV type 1 infection of plasmacytoid and myeloid dendritic cells is restricted by high levels of SAMHD1 and cannot be counteracted by Vpx. - Test2 - elhamkhani - TriplyDB

HIV type 1 infection of plasmacytoid and myeloid dendritic cells is restricted by high levels of SAMHD1 and cannot be counteracted by Vpx.

HIV type 1 infection of plasmacytoid and myeloid dendritic cells is restricted by high levels of SAMHD1 and cannot be counteracted by Vpx.

http://www.wikidata.org/entity/Q37543254

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New insights into an X-traordinary viral protein Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1 Friend or Foe: Innate Sensing of HIV in the Female Reproductive Tract.Neutralizing antibodies inhibit HIV-1 infection of plasmacytoid dendritic cells by an FcγRIIa independent mechanism and do not diminish cytokines production.Broadly neutralizing antibody VRC01 prevents HIV-1 transmission from plasmacytoid dendritic cells to CD4 T lymphocytes.Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells.Dendritic cells in progression and pathology of HIV infection.SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells.Complement-Opsonized HIV-1 Overcomes Restriction in Dendritic Cells.Phenotypic and Functional Characterization of Monoclonal Antibodies with Specificity for Rhesus Macaque CD200, CD200R and Mincle HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent Mechanisms CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells.SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load.Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections.SIV vpx is essential for macrophage infection but not for development of AIDS.Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.Dendritic cell-lymphocyte cross talk downregulates host restriction factor SAMHD1 and stimulates HIV-1 replication in dendritic cells Constitutive resistance to viral infection in human CD141+ dendritic cells.The Significance of Type-I Interferons in the Pathogenesis and Therapy of Human Immunodeficiency Virus 1 Infection.The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis.Lentiviral infection of proliferating brain macrophages in HIV and simian immunodeficiency virus encephalitis despite sterile alpha motif and histidine-aspartate domain-containing protein 1 expression.

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HIV type 1 infection of plasmacytoid and myeloid dendritic cells is restricted by high levels of SAMHD1 and cannot be counteracted by Vpx.

http://www.wikidata.org/entity/Q37543254

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 04 September 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

HIV type 1 infection of plasma ...... cannot be counteracted by Vpx.

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HIV type 1 infection of plasma ...... cannot be counteracted by Vpx.

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type

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HIV type 1 infection of plasma ...... cannot be counteracted by Vpx.

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HIV type 1 infection of plasma ...... cannot be counteracted by Vpx.

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prefLabel

HIV type 1 infection of plasma ...... cannot be counteracted by Vpx.

@en

HIV type 1 infection of plasma ...... cannot be counteracted by Vpx.

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AIDS Research and Human Retroviruses

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HIV type 1 infection of plasma ...... cannot be counteracted by Vpx.

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Meagan O'Brien

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Nathaniel R Landau

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Nicolin Bloch

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Nina Bhardwaj

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Sylvie B Polsky

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Thomas D Norton

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P2860

SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection

Plasmacytoid dendritic cells: linking innate and adaptive immunity

Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

Function and regulation of cullin-RING ubiquitin ligases

DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells

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195-203

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scholarly article

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10.1089/AID.2013.0119

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2

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30

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2013-09-04T00:00:00Z

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23924154

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3910455

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