Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. - Test2 - elhamkhani - TriplyDB

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.

http://www.wikidata.org/entity/Q37548268

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Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders Role of the Retromer Complex in Neurodegenerative Diseases Dissecting Alzheimer disease in Down syndrome using mouse models Non-muscle myosin II in disease: mechanisms and therapeutic opportunities Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders.Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells.A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex VPS35 regulates cell surface recycling and signaling of dopamine receptor D1 Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving the DPYD enigma GIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behavior A role for sorting nexin 27 in AMPA receptor trafficking.The use of pharmacological retromer chaperones in Alzheimer's disease and other endosomal-related disorders.Co-expression network analysis of Down's syndrome based on microarray data.Endocytosis, signaling, and beyond Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs.Sorting nexin 27 regulation of G protein-gated inwardly rectifying K⁺ channels attenuates in vivo cocaine response.A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer.Mutations in SNX14 cause a distinctive autosomal-recessive cerebellar ataxia and intellectual disability syndrome.TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia.SNX16 negatively regulates the migration and tumorigenesis of MCF-7 cells Dysregulation of protein trafficking in neurodegeneration.Parent ratings of ability to consent for clinical trials in fragile X syndrome.ER to synapse trafficking of NMDA receptors Genome-wide miR-155 and miR-802 target gene identification in the hippocampus of Ts65Dn Down syndrome mouse model by miRNA sponges Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity.Snx14 regulates neuronal excitability, promotes synaptic transmission, and is imprinted in the brain of mice.The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.The Orphan Nuclear Receptor TLX Is an Enhancer of STAT1-Mediated Transcription and Immunity to Toxoplasma gondii.Sorting nexin 27 regulates basal and stimulated brush border trafficking of NHE3.Epitope Fingerprinting for Recognition of the Polyclonal Serum Autoantibodies of Alzheimer's Disease.The GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis.Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors.Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP Sorting nexin 27 interacts with Fzd7 and mediates Wnt signalling.Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination.Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth.A role for novel lipid interactions in the dynamic recruitment of SNX27 to the T-cell immune synapse

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Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.

http://www.wikidata.org/entity/Q37548268

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 24 March 2013

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Loss of sorting nexin 27 contr ...... recycling in Down's syndrome.

@en

Loss of sorting nexin 27 contr ...... recycling in Down's syndrome.

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type

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Loss of sorting nexin 27 contr ...... recycling in Down's syndrome.

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Loss of sorting nexin 27 contr ...... recycling in Down's syndrome.

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prefLabel

Loss of sorting nexin 27 contr ...... recycling in Down's syndrome.

@en

Loss of sorting nexin 27 contr ...... recycling in Down's syndrome.

@nl

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Nature Medicine

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Loss of sorting nexin 27 contr ...... r recycling in Down's syndrome

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Barbara Ranscht

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Bo Yang

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Chengbiao Wu

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Dongxian Zhang

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Fred H Gage

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Guojun Bu

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Hedieh Badie

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Huaxi Xu

http://www.w3.org/2001/XMLSchema#string

Lei Cai

http://www.w3.org/2001/XMLSchema#string

Li Shen Loo

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P2860

SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane

SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors.

A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression

Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C)

Trisomy-21 gene dosage over-expression of miRNAs results in the haploinsufficiency of specific target proteins

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation

Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27

Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases

New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting

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473-480

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scholarly article

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10.1038/NM.3117

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4

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19

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Peter F. Johnson

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2013-03-24T00:00:00Z

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236076145

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23524343

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3911880

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