New tricks for old dogs: KCNQ expression and role in smooth muscle.
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From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl groupPotent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitusExpression and function of the K+ channel KCNQ genes in human arteries.Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2BKV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus.Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine.The Effects of the KCNQ Openers Retigabine and Flupirtine on Myotonia in Mammalian Skeletal Muscle Induced by a Chloride Channel Blocker.The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and ContractilityClinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy.Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries.Novel Roles for Kv7 Channels in Shaping Histamine-Induced Contractions and Bradykinin-Dependent Relaxations in Pig Coronary Arteries.One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders.Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channelsFunctional effects of KCNQ K(+) channels in airway smooth muscleMolecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth musclesPharmacological modulation of voltage-gated potassium channels as a therapeutic strategy.Vasodilator signals from perivascular adipose tissue.Role of vascular potassium channels in the regulation of renal hemodynamics.The urinary safety profile and secondary renal effects of retigabine (ezogabine): a first-in-class antiepileptic drug that targets KCNQ (K(v)7) potassium channels.Distribution of M-channel subunits KCNQ2 and KCNQ3 in rat hippocampusModulation of Kv7 channels and excitability in the brain.Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth.Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Role of renal vascular potassium channels in physiology and pathophysiology.KV7 channels in the human detrusor: channel modulator effects and gene and protein expression.Targeting of Kv7.5 (KCNQ5)/KCNE channels to surface microdomains of cell membranes.Investigation of the impact of urine handling procedures on interpretation of urinalysis findings and product safety in subjects treated with ezogabine.A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P₂.The Voltage-Sensing Domain of K(v)7.2 Channels as a Molecular Target for Epilepsy-Causing Mutations and Anticonvulsants.Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter.KV channels and the regulation of vascular smooth muscle tone.Do KV 7.1 channels contribute to control of arterial vascular tone?Selective activation of vascular Kv 7.4/Kv 7.5 K+ channels by fasudil contributes to its vasorelaxant effect.The Unexpected Role of Calcium-Activated Potassium Channels: Limitation of NO-Induced Arterial Relaxation.Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators.Kv7(KCNQ)-K+-Channels Influence Total Peripheral Resistance in Female but Not Male Rats, and Hamper Catecholamine Release in Hypertensive Rats of Both Sexes.Activation of KCNQ channels located on the skeletal muscle membrane by retigabine and its influence on the maximal muscle force in rat muscle strips.Under pressure - Kv channels and myogenic control of cerebral blood flow
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New tricks for old dogs: KCNQ expression and role in smooth muscle.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
New tricks for old dogs: KCNQ expression and role in smooth muscle.
@en
New tricks for old dogs: KCNQ expression and role in smooth muscle.
@nl
type
label
New tricks for old dogs: KCNQ expression and role in smooth muscle.
@en
New tricks for old dogs: KCNQ expression and role in smooth muscle.
@nl
prefLabel
New tricks for old dogs: KCNQ expression and role in smooth muscle.
@en
New tricks for old dogs: KCNQ expression and role in smooth muscle.
@nl
P2860
P1476
New tricks for old dogs: KCNQ expression and role in smooth muscle.
@en
P2093
Susumu Ohya
P2860
P304
P356
10.1111/J.1476-5381.2009.00131.X
P407
P577
2009-04-01T00:00:00Z