The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation
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SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcriptionThe second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigmaCD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturationCD45 and RPTPalpha display different protein tyrosine phosphatase activities in T lymphocytesA supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activationReduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis.Protein tyrosine phosphatases as potential therapeutic targets.CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cellsclr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans.Viral interference with functions of the cellular receptor tyrosine phosphatase CD45.Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity.Vitamin E reverses impaired linker for activation of T cells activation in T cells from aged C57BL/6 mice.Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity.Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering.Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation.Epitope-specific crosslinking of CD45 down-regulates membrane-associated tyrosine phosphatase activity and triggers early signalling events in human activated T cells.
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P2860
The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1994
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The catalytic activity of the ...... r TCR signaling and regulation
@en
The catalytic activity of the ...... TCR signaling and regulation.
@nl
type
label
The catalytic activity of the ...... r TCR signaling and regulation
@en
The catalytic activity of the ...... TCR signaling and regulation.
@nl
prefLabel
The catalytic activity of the ...... r TCR signaling and regulation
@en
The catalytic activity of the ...... TCR signaling and regulation.
@nl
P2093
P2860
P1433
P1476
The catalytic activity of the ...... r TCR signaling and regulation
@en
P2093
J Schlessinger
O Silvennoinen
P2860
P304
P356
10.1002/J.1460-2075.1994.TB06716.X
P407
P577
1994-09-01T00:00:00Z