Development of an efficient, scalable, aldolase-catalyzed process for enantioselective synthesis of statin intermediates
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Structural insight for substrate tolerance to 2-deoxyribose-5-phosphate aldolase from the pathogen Streptococcus suisChemoenzymatic synthesis of building blocks for statin side chains.A highly productive, whole-cell DERA chemoenzymatic process for production of key lactonized side-chain intermediates in statin synthesisRedesigning Aldolase Stereoselectivity by Homologous Grafting.Carbonylation of epoxides to substituted 3-hydroxy-delta-lactones.Metabolic engineering is key to a sustainable chemical industry.DHAP-dependent aldolases from (hyper)thermophiles: biochemistry and applications.Engineering aldolases as biocatalysts.Alternative hosts for functional (meta)genome analysis.A Retrosynthesis Approach for Biocatalysis in Organic Synthesis.Accelerating Enzymatic Catalysis Using Vortex Fluidics.Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin.Characterization and application of a newly synthesized 2-deoxyribose-5-phosphate aldolase.Hyperthermophilic aldolases as biocatalyst for C-C bond formation: rhamnulose 1-phosphate aldolase from Thermotoga maritima.Inter- and intramolecular aldol reactions promiscuously catalyzed by a proline-based tautomerase.1H, 13C, and 15N backbone and sidechain resonance assignments of a monomeric variant of E. coli deoxyribose-5-phosphate aldolase.A comparative study on phosphotransferase activity of acid phosphatases from Raoultella planticola and Enterobacter aerogenes on nucleosides, sugars, and related compounds.Efficient production of 2-deoxyribose 5-phosphate from glucose and acetaldehyde by coupling of the alcoholic fermentation system of Baker's yeast and deoxyriboaldolase-expressing Escherichia coli.Conformational Sampling of the Intrinsically Disordered C-Terminal Tail of DERA Is Important for Enzyme CatalysisDiscovery and Protein Engineering of Biocatalysts for Organic SynthesisMechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategiesRu-catalyzed hydrogenation of 3,5-diketo amides: simultaneous control of chemo- and enantioselectivity
P2860
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P2860
Development of an efficient, scalable, aldolase-catalyzed process for enantioselective synthesis of statin intermediates
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 06 April 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Development of an efficient, s ...... thesis of statin intermediates
@en
Development of an efficient, s ...... hesis of statin intermediates.
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type
label
Development of an efficient, s ...... thesis of statin intermediates
@en
Development of an efficient, s ...... hesis of statin intermediates.
@nl
prefLabel
Development of an efficient, s ...... thesis of statin intermediates
@en
Development of an efficient, s ...... hesis of statin intermediates.
@nl
P2093
P2860
P356
P1476
Development of an efficient, s ...... thesis of statin intermediates
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P2093
Alexander Varvak
Hongjun Huang
Kelvin Wong
Mark J Burk
Sarah R Hanson
William A Greenberg
P2860
P304
P356
10.1073/PNAS.0307563101
P407
P577
2004-04-06T00:00:00Z