Primary demyelination in transgenic mice expressing interferon-gamma
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First-Line Disease-Modifying Therapies in Paediatric Multiple SclerosisTherapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cellsNK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ-IL-27 axis.Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitisIn vitro and in vivo induction and activation of nNOS by LPS in oligodendrocytesProtection from lethal coxsackievirus-induced pancreatitis by expression of gamma interferon.Coronavirus-induced demyelination occurs in the absence of inducible nitric oxide synthaseExpression of immunoregulatory cytokines by recombinant coxsackievirus B3 variants confers protection against virus-caused myocarditisTransgenic models for cytokine-induced neurological disease.Central nervous system pathology caused by autoreactive CD8+ T-cell clones following virus infectionInterferon-γ activates nuclear factor-κ B in oligodendrocytes through a process mediated by the unfolded protein response.Glial cells as targets for cytotoxic immune mediators.Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs.Deleterious role of IFNgamma in a toxic model of central nervous system demyelinationCerebral expression of interleukin-12 induces neurological disease via differential pathways and recruits antigen-specific T cells in virus-infected mice.Interleukin-18 and host defense against infection.Molecular pathogenesis of neuroinflammation.Vaccination procedures against Coxsackievirus-induced heart disease.The role of bystander T cells in CNS pathology and pathogen clearance.Selective abrogation of major histocompatibility complex class II expression on extrahematopoietic cells in mice lacking promoter IV of the class II transactivator gene.A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis.CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies.Hypothyroidism in transgenic mice expressing IFN-gamma in the thyroidTumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present.A new approach for evaluating antigen-specific T cell responses to myelin antigens during the course of multiple sclerosis.Enhancing remyelination in disease--can we wrap it up?Melatonin reduces inflammatory response in peripheral T helper lymphocytes from relapsing-remitting multiple sclerosis patients.Opposing Roles of Interferon-Gamma on Cells of the Central Nervous System in Autoimmune Neuroinflammation.A partially humanized monoclonal antibody to human IFN-gamma inhibits cytokine effects both in vitro and in vivo.Pancreatic expression of interferon-gamma protects mice from lethal coxsackievirus B3 infection and subsequent myocarditis.Lipoic acid stimulates cAMP production via the EP2 and EP4 prostanoid receptors and inhibits IFN gamma synthesis and cellular cytotoxicity in NK cells.Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification.Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats.Cytokines induce nitric oxide-mediated mtDNA damage and apoptosis in oligodendrocytes. Protective role of targeting 8-oxoguanine glycosylase to mitochondria.MEK-ERK signaling is involved in interferon-gamma-induced death of oligodendroglial progenitor cells.The control of oligodendrocyte bioenergetics by interferon-gamma (IFN-γ) and Src homology region 2 domain-containing phosphatase-1 (SHP-1).Site-specific immune regulation in the brain: differential modulation of major histocompatibility complex (MHC) proteins in brainstem vs. hippocampus.Reaction of mouse brain oligodendrocytes and their precursors, astrocytes and microglia, to proinflammatory mediators circulating in the cerebrospinal fluid.LPS/IFN-gamma cytotoxicity in oligodendroglial cells: role of nitric oxide and protection by the anti-inflammatory cytokine IL-10.A Role for Interferon-Gamma in Focal Cerebral Ischemia in Mice
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Primary demyelination in transgenic mice expressing interferon-gamma
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on September 1997
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Primary demyelination in transgenic mice expressing interferon-gamma
@en
Primary demyelination in transgenic mice expressing interferon-gamma.
@nl
type
label
Primary demyelination in transgenic mice expressing interferon-gamma
@en
Primary demyelination in transgenic mice expressing interferon-gamma.
@nl
prefLabel
Primary demyelination in transgenic mice expressing interferon-gamma
@en
Primary demyelination in transgenic mice expressing interferon-gamma.
@nl
P2093
P2860
P356
P1433
P1476
Primary demyelination in transgenic mice expressing interferon-gamma
@en
P2093
Claire F Evans
Marc S Horwitz
Michael B A Oldstone
Moses Rodriguez
P2860
P2888
P304
P356
10.1038/NM0997-1037
P407
P577
1997-09-01T00:00:00Z