Hedgehog beyond medulloblastoma and basal cell carcinoma.
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Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effectorItraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonistsTamoxifen Resistance: Emerging Molecular TargetsCiliogenesis and the DNA damage response: a stressful relationshipDifferential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date reviewHedgehog Signaling in the Maintenance of Cancer Stem CellsHedgehog Signaling in Malignant Pleural MesotheliomaRoles for Hedgehog signaling in adult organ homeostasis and repairCooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapyBasal cell carcinoma - molecular biology and potential new therapiesHedgehog signaling pathway and its targets for treatment in basal cell carcinomaContext-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapyIn vivo imaging of Hedgehog pathway activation with a nuclear fluorescent reporterStromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth.Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitorsTargeted destruction of the orchestration of the pancreatic stroma and tumor cells in pancreatic cancer cases: molecular basis for therapeutic implicationsNovel mechanism of action on Hedgehog signaling by a suppressor of fused carboxy terminal variantProtein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tubeDYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistanceThe primary cilium: a signalling centre during vertebrate developmentBifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration.Autocrine Sonic hedgehog attenuates inflammation in cerulein-induced acute pancreatitis in mice via upregulation of IL-10.Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathwaysCombined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia.Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis.Up-regulation of sonic hedgehog contributes to TGF-β1-induced epithelial to mesenchymal transition in NSCLC cellsInhibition of hedgehog signaling decreases proliferation and clonogenicity of human mesenchymal stem cells.GPCRs and cancerChemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathwaysHedgehog signaling in the normal and neoplastic mammary gland.GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent stateArhgap36-dependent activation of Gli transcription factors.Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms.Clinicopathological correlation and prognostic significance of sonic hedgehog protein overexpression in human gastric cancerA critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance.MicroRNA-203 functions as a tumor suppressor in basal cell carcinomaArsenic: a potentially useful poison for Hedgehog-driven cancers.Sonic hedgehog signaling in the lung. From development to disease.
P2860
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P2860
Hedgehog beyond medulloblastoma and basal cell carcinoma.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 18 January 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Hedgehog beyond medulloblastoma and basal cell carcinoma.
@en
Hedgehog beyond medulloblastoma and basal cell carcinoma.
@nl
type
label
Hedgehog beyond medulloblastoma and basal cell carcinoma.
@en
Hedgehog beyond medulloblastoma and basal cell carcinoma.
@nl
prefLabel
Hedgehog beyond medulloblastoma and basal cell carcinoma.
@en
Hedgehog beyond medulloblastoma and basal cell carcinoma.
@nl
P1476
Hedgehog beyond medulloblastoma and basal cell carcinoma.
@en
P2093
Rune Toftgård
Stephan Teglund
P304
P356
10.1016/J.BBCAN.2010.01.003
P407
P577
2010-01-18T00:00:00Z