SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis. - Test2 - elhamkhani - TriplyDB

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis.

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis.

http://www.wikidata.org/entity/Q37688362

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Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis Honokiol inhibits ultraviolet radiation-induced immunosuppression through inhibition of ultraviolet-induced inflammation and DNA hypermethylation in mouse skin.Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts.SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis.Epigenetic factors as drivers of fibrosis in systemic sclerosis.SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis.Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice.Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells.Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis.Sirtuins and Accelerated Aging in Scleroderma.Entanglement of GSK-3β, β-catenin and TGF-β1 signaling network to regulate myocardial fibrosis.Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease.A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic Sclerosis Epigenetic Regulation of Myofibroblast Phenotypes in Fibrosis PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses Mitochondrial Deacetylase SIRT3 Plays an Important Role in Donor T Cell Responses after Experimental Allogeneic Hematopoietic Transplantation

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SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis.

http://www.wikidata.org/entity/Q37688362

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

@tr

scientific article published on 06 October 2016

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

SIRT3 is attenuated in systemi ...... tion mitigates organ fibrosis.

@en

SIRT3 is attenuated in systemi ...... tion mitigates organ fibrosis.

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type

label

SIRT3 is attenuated in systemi ...... tion mitigates organ fibrosis.

@en

SIRT3 is attenuated in systemi ...... tion mitigates organ fibrosis.

@nl

prefLabel

SIRT3 is attenuated in systemi ...... tion mitigates organ fibrosis.

@en

SIRT3 is attenuated in systemi ...... tion mitigates organ fibrosis.

@nl

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ONCOTARGET.12504

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SIRT3 is attenuated in systemi ...... tion mitigates organ fibrosis.

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David W Kamp

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Jack L Arbiser

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John Varga

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Jun Wei

http://www.w3.org/2001/XMLSchema#string

Kaname Akamata

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Kirtee Raparia

http://www.w3.org/2001/XMLSchema#string

Mahesh P Gupta

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Michael Y Bonner

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Mitra Bhattacharyya

http://www.w3.org/2001/XMLSchema#string

Paul Cheresh

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Sirtuins: Sir2-related NAD-dependent protein deacetylases

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Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts

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Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo

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TGF-β1-mediated differentiation of fibroblasts is associated with increased mitochondrial content and cellular respiration

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69321-69336

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scholarly article

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10.18632/ONCOTARGET.12504

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