The therapeutic promise of positive allosteric modulation of nicotinic receptors.
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Treating Negative Symptoms in Schizophrenia: an UpdateOrthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking CessationnAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives.Maximizing the effect of an α7 nicotinic receptor PAM in a mouse model of schizophrenia-like sensory inhibition deficits.Beyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties.Photoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites.High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: proof-of-conceptFunctional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor.Alpha-7 nicotinic agonists for cognitive deficits in neuropsychiatric disorders: A translational meta-analysis of rodent and human studies.Pro-cognitive activity in rats of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptorCompetition, Selectivity and Efficacy of Analogs of A-84543 for Nicotinic Acetylcholine Receptors with Repositioning of Pyridine Nitrogen.Alterations in Cholinergic Pathways and Therapeutic Strategies Targeting Cholinergic System after Traumatic Brain Injury.Understanding the Bases of Function and Modulation of α7 Nicotinic Receptors: Implications for Drug Discovery.Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca(2+) release from the endoplasmic reticulum.The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors.Nicotinic acetylcholine receptors at the single-channel level.Cholinergic modulation of the immune system presents new approaches for treating inflammation.α9-containing nicotinic acetylcholine receptors and the modulation of pain.Insights into nicotinic receptor signaling in nicotine addiction: Implications for prevention and treatment.Effects of nicotine in combination with drugs described as positive allosteric nicotinic acetylcholine receptor modulators in vitro: discriminative stimulus and hypothermic effects in mice.Expression and Functional Role of α7 Nicotinic Receptor in Human Cytokine-stimulated Natural Killer (NK) CellsReversal of Nicotine Withdrawal Signs through Positive Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors in Male Mice.An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine binding protein.Molecular function of α7 nicotinic receptors as drug targets.Nicotinic acetylcholine receptors in neuropathic and inflammatory pain.LY2087101 and dFBr share transmembrane binding sites in the (α4)3(β2)2 Nicotinic Acetylcholine Receptor.Molecular function of the novel α7β2 nicotinic receptor.Stimulation of nicotinic acetylcholine alpha7 receptors rescue schizophrenia-like cognitive impairments in rats.Boosting Endogenous Resistance of Brain to Ischemia.Attenuation of nicotine taking and seeking in rats by the stoichiometry-selective alpha4beta2 nicotinic acetylcholine receptor positive allosteric modulator NS9283.
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P2860
The therapeutic promise of positive allosteric modulation of nicotinic receptors.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 February 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The therapeutic promise of positive allosteric modulation of nicotinic receptors.
@en
The therapeutic promise of positive allosteric modulation of nicotinic receptors.
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type
label
The therapeutic promise of positive allosteric modulation of nicotinic receptors.
@en
The therapeutic promise of positive allosteric modulation of nicotinic receptors.
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prefLabel
The therapeutic promise of positive allosteric modulation of nicotinic receptors.
@en
The therapeutic promise of positive allosteric modulation of nicotinic receptors.
@nl
P2860
P1476
The therapeutic promise of positive allosteric modulation of nicotinic receptors.
@en
P2093
Victor V Uteshev
P2860
P304
P356
10.1016/J.EJPHAR.2014.01.072
P407
P577
2014-02-12T00:00:00Z