Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats
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Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortexEvaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia.High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: proof-of-conceptEffects of α7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models.Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT₁a receptor antagonist.Alterations in Cholinergic Pathways and Therapeutic Strategies Targeting Cholinergic System after Traumatic Brain Injury.Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies.The activity of GAT107, an allosteric activator and positive modulator of α7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interface.The therapeutic promise of positive allosteric modulation of nicotinic receptors.Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia.Can neurostimulation prevent the risk of Alzheimer's disease in elderly individuals with schizophrenia?Targeting brain α7 nicotinic acetylcholine receptors in Alzheimer's disease: rationale and current status.Therapeutic improvements expected in the near future for schizophrenia and schizoaffective disorder: an appraisal of phase III clinical trials of schizophrenia-targeted therapies as found in US and EU clinical trial registries.AVP-786 for the treatment of agitation in dementia of the Alzheimer's type.First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288.The alpha-7 nicotinic receptor partial agonist/5-HT3 antagonist RG3487 enhances cortical and hippocampal dopamine and acetylcholine release.The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials.Expression of the Ly-6 family proteins Lynx1 and Ly6H in the rat brain is compartmentalized, cell-type specific, and developmentally regulated.Stimulation of nicotinic acetylcholine alpha7 receptors rescue schizophrenia-like cognitive impairments in rats.
P2860
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P2860
Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats
description
2011 nî lūn-bûn
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2011 թուականին հրատարակուած գիտական յօդուած
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2011 թվականին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
Differential immediate and sus ...... allosteric modulators in rats
@ast
Differential immediate and sus ...... allosteric modulators in rats
@en
Differential immediate and sus ...... allosteric modulators in rats
@nl
type
label
Differential immediate and sus ...... allosteric modulators in rats
@ast
Differential immediate and sus ...... allosteric modulators in rats
@en
Differential immediate and sus ...... allosteric modulators in rats
@nl
prefLabel
Differential immediate and sus ...... allosteric modulators in rats
@ast
Differential immediate and sus ...... allosteric modulators in rats
@en
Differential immediate and sus ...... allosteric modulators in rats
@nl
P2860
P1433
P1476
Differential immediate and sus ...... allosteric modulators in rats
@en
P2093
Mona El-Sayed
Morten S Thomsen
P2860
P304
P356
10.1371/JOURNAL.PONE.0027014
P407
P577
2011-01-01T00:00:00Z