Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.
about
Sequence co-evolutionary information is a natural partner to minimally-frustrated models of biomolecular dynamicsA point mutation in the [2Fe–2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor propertiesRobust and accurate prediction of residue-residue interactions across protein interfaces using evolutionary information.Applications of hydrogen/deuterium exchange MS from 2012 to 2014.The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer.Dimeric interactions and complex formation using direct coevolutionary couplings.Interactions between mitoNEET and NAF-1 in cells.CISD2 associated with proliferation indicates negative prognosis in patients with hepatocellular carcinomaActivation of apoptosis in NAF-1-deficient human epithelial breast cancer cellsAffinity purification-mass spectrometry analysis of bcl-2 interactome identified SLIRP as a novel interacting protein.Orphan Nuclear Receptor NR4A1 Binds a Novel Protein Interaction Site on Anti-apoptotic B Cell Lymphoma Gene 2 Family Proteins.iTRAQ-Based Proteomic Analysis of Ginsenoside F2 on Human Gastric Carcinoma Cells SGC7901.Elucidating the druggable interface of protein-protein interactions using fragment docking and coevolutionary analysis.Conservation of coevolving protein interfaces bridges prokaryote-eukaryote homologies in the twilight zone.NAF-1 antagonizes starvation-induced autophagy through AMPK signaling pathway in cardiomyocytes.CISD2 enhances the chemosensitivity of gastric cancer through the enhancement of 5-FU-induced apoptosis and the inhibition of autophagy by AKT/mTOR pathway.The unique fold and lability of the [2Fe-2S] clusters of NEET proteins mediate their key functions in health and disease.Autophagy and Ferroptosis - What's the Connection?Phylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin.
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Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 25 March 2014
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.
@en
Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.
@nl
type
label
Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.
@en
Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.
@nl
prefLabel
Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.
@en
Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.
@nl
P2093
P2860
P356
P1476
Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.
@en
P2093
Andrea R Conlan
Assaf Friedler
Charles Wang
Colin H Lipper
Faruck Morcos
John A Zuris
Kendra L Hailey
Mark L Paddock
Patricia A Jennings
P2860
P304
P356
10.1073/PNAS.1403770111
P407
P577
2014-03-25T00:00:00Z