Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1. - Test2 - elhamkhani - TriplyDB

Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.

Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.

http://www.wikidata.org/entity/Q37702086

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Sequence co-evolutionary information is a natural partner to minimally-frustrated models of biomolecular dynamics A point mutation in the [2Fe–2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties Robust and accurate prediction of residue-residue interactions across protein interfaces using evolutionary information.Applications of hydrogen/deuterium exchange MS from 2012 to 2014.The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer.Dimeric interactions and complex formation using direct coevolutionary couplings.Interactions between mitoNEET and NAF-1 in cells.CISD2 associated with proliferation indicates negative prognosis in patients with hepatocellular carcinoma Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cells Affinity purification-mass spectrometry analysis of bcl-2 interactome identified SLIRP as a novel interacting protein.Orphan Nuclear Receptor NR4A1 Binds a Novel Protein Interaction Site on Anti-apoptotic B Cell Lymphoma Gene 2 Family Proteins.iTRAQ-Based Proteomic Analysis of Ginsenoside F2 on Human Gastric Carcinoma Cells SGC7901.Elucidating the druggable interface of protein-protein interactions using fragment docking and coevolutionary analysis.Conservation of coevolving protein interfaces bridges prokaryote-eukaryote homologies in the twilight zone.NAF-1 antagonizes starvation-induced autophagy through AMPK signaling pathway in cardiomyocytes.CISD2 enhances the chemosensitivity of gastric cancer through the enhancement of 5-FU-induced apoptosis and the inhibition of autophagy by AKT/mTOR pathway.The unique fold and lability of the [2Fe-2S] clusters of NEET proteins mediate their key functions in health and disease.Autophagy and Ferroptosis - What's the Connection?Phylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin.

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Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.

http://www.wikidata.org/entity/Q37702086

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 25 March 2014

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

@cs

name

Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.

@en

Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.

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type

label

Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.

@en

Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.

@nl

prefLabel

Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.

@en

Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.

@nl

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PNAS.1403770111

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Proceedings of the National Academy of Sciences of the United States of America

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Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.

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Andrea R Conlan

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Assaf Friedler

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Charles Wang

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Chen Katz

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Colin H Lipper

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Faruck Morcos

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John A Zuris

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Kendra L Hailey

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Mark L Paddock

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Patricia A Jennings

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P2860

Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1

Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2

The structure and interactions of the proline-rich domain of ASPP2

Direct-coupling analysis of residue coevolution captures native contacts across many protein families

Solution structure of the antiapoptotic protein bcl-2

UCSF Chimera--a visualization system for exploratory research and analysis

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

Nutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugs

Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice

The BCL-2 protein family: opposing activities that mediate cell death

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5177-5182

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scholarly article

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10.1073/PNAS.1403770111

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14

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111

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Rachel Nechushtai

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2014-03-25T00:00:00Z

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261409894

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