Emerging biological importance of central nervous system lanthionines.
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Glutathione conjugation of busulfan produces a hydroxyl radical-trapping dehydroalanine metaboliteMoving towards effective therapeutic strategies for Neuronal Ceroid LipofuscinosisAlternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagementImine reductases: a comparison of glutamate dehydrogenase to ketimine reductases in the brainA cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologiesG-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2Collapsin response mediator protein 2: high-resolution crystal structure sheds light on small-molecule binding, post-translational modifications, and conformational flexibility.Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines.Semaphorin 3A signaling through neuropilin-1 is an early trigger for distal axonopathy in the SOD1G93A mouse model of amyotrophic lateral sclerosisProgress in therapy development for amyotrophic lateral sclerosisStructure and mechanism of lanthipeptide biosynthetic enzymes.Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia.Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in actinobacteriaRedox regulation of autophagy in healthy brain and neurodegeneration.Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine β-synthase: a target for neuronal antioxidant defense.A derivative of the CRMP2 binding compound lanthionine ketimine provides neuroprotection in a mouse model of cerebral ischemia.Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders.Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein TauLanCL proteins are not Involved in Lanthionine Synthesis in Mammals.Collapsin response mediator protein-2: an emerging pathologic feature and therapeutic target for neurodisease indications.CRMPs Function in Neurons and Glial Cells: Potential Therapeutic Targets for Neurodegenerative Diseases and CNS Injury.The Axon Guidance Protein Semaphorin 3A Is Increased in the Motor Cortex of Patients With Amyotrophic Lateral Sclerosis.Reciprocal Control of Thyroid Binding and the Pipecolate Pathway in the Brain.HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology.Lanthionine ketimine ester provides benefit in a mouse model of multiple sclerosis.Multiple-step, one-pot synthesis of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates and their corresponding ethyl esters.Lanthionine ketimine ethyl ester partially rescues neurodevelopmental defects in unc-33 (DPYSL2/CRMP2) mutants.Lanthionine ketimine-5-ethyl ester provides neuroprotection in a zebrafish model of okadaic acid-induced Alzheimer's disease.
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Emerging biological importance of central nervous system lanthionines.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 13 August 2010
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Emerging biological importance of central nervous system lanthionines.
@en
Emerging biological importance of central nervous system lanthionines.
@nl
type
label
Emerging biological importance of central nervous system lanthionines.
@en
Emerging biological importance of central nervous system lanthionines.
@nl
prefLabel
Emerging biological importance of central nervous system lanthionines.
@en
Emerging biological importance of central nervous system lanthionines.
@nl
P2093
P1433
P1476
Emerging biological importance of central nervous system lanthionines
@en
P2093
Alexandar Christov
Kalina Venkova
Kenneth Hensley
P304
P356
10.3390/MOLECULES15085581
P407
P577
2010-08-13T00:00:00Z