about
A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomasTargeting Pim kinases for cancer treatment: opportunities and challengesPIM1 kinase as a target for cancer therapyPim-1 kinase as cancer drug target: An updateSmall molecule inhibitors of PIM1 kinase: July 2009 to February 2013 patent updateRNAi screen identifies a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibitionTrichomonosis, a common curable STI, and prostate carcinogenesis--a proposed molecular mechanism.The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells.Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinomaExpression of pim-1 in tumors, tumor stroma and tumor-adjacent mucosa co-determines the prognosis of colon cancer patients.PIM kinase inhibitor AZD1208 for treatment of MYC-driven prostate cancerPIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation.Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells.PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinomaPim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry.MicroRNA-101-3p suppresses cell proliferation, invasion and enhances chemotherapeutic sensitivity in salivary gland adenoid cystic carcinoma by targeting Pim-1.PIM1 polymorphism and PIM1 expression as predisposing factors of esophageal squamous cell carcinoma in the Asian population.Identification of quinones as novel PIM1 kinase inhibitorsTargeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition.PIM kinases as therapeutic targets against advanced melanoma.Design and Synthesis of Potent and Selective PIM Kinase Inhibitors by Targeting Unique Structure of ATP-Binding Pocket.PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.Discovery and identification of PIM-1 kinase inhibitors through a hybrid screening approach.Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine.PIM1: a promising target in patients with triple-negative breast cancer.PIM-1 mRNA expression is a potential prognostic biomarker in acute myeloid leukemia.Pim-1: A new biomarker in pulmonary arterial hypertension.HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372.Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors.Label-free fluorescence detection of kinase activity using a gold nanoparticle based indicator displacement assay.Thyroid hormone inhibits growth of hepatoma cells through induction of miR-214.Expression of PIM-1 in salivary gland adenoid cystic carcinoma: Association with tumor progression and patients' prognosis.Loss of PIM1 correlates with progression and prognosis of salivary adenoid cystic carcinoma (SACC).Selective bisubstrate inhibitors with sub-nanomolar affinity for protein kinase Pim-1.Pim1 supports human colorectal cancer growth during glucose deprivation by enhancing the Warburg effect.Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2/STAT3 signaling in colorectal cancer.Pim1 promotes cell proliferation and regulates glycolysis via interaction with MYC in ovarian cancer
P2860
Q28242549-6A85F58A-4AEE-462C-A9F3-56D6E5899A92Q28255361-8D22BC0C-EAB1-467D-BA85-F06A483E7BC6Q28261162-20C2A651-A364-4204-8106-D19B97A13FE9Q28273475-703D6730-8940-4D67-825F-807B8351E8F8Q28300334-9277A633-3C57-4C7C-AA9D-A28A1359B9BBQ33861057-64A531A2-A2CA-4818-B575-BF6869083FB8Q34388442-A28BEEB2-691C-4D56-A220-15E2750EDF09Q34494886-ACC3BBE0-5083-4564-A73A-FB2E261EA315Q35005230-4C5BBCB6-7270-4872-8347-63D1FCBF5A43Q35014814-078CFAC7-CCEA-4198-9FD0-F174BCB5C82AQ35078578-66917068-936F-4D84-A85B-B40DFCCAF299Q35093045-DBDDB423-E742-44FE-A038-DC93A36EB562Q35571648-A0B2D8EA-5C0F-4EE5-8031-FC738B0890AEQ35793653-B6951F18-E47A-4C70-A045-3455326F7B5EQ36080785-DBFE77B9-F596-4D2A-BBED-FA1B145DE8C5Q36309379-24FFDBE4-31A4-4A45-B6AC-8BE71FC01629Q36924453-C2297D35-913D-49E1-96DA-4D4CC7734EAAQ36984044-32448271-72AA-4C5F-B260-87AA9BBBCB81Q37362875-41861905-A51D-4676-953B-28E0F2DB63C8Q37688157-C8227B59-9D22-41AE-8EA7-A7B8BAB74B0DQ38681971-85B7B384-44DF-4BAC-896A-ED7F566C3205Q38735131-61FDA679-DE1B-478F-A573-E3DFCDB3D4F0Q39024729-44229F42-803A-4F94-927B-83329AB75418Q39140386-C1A85AFF-7053-4540-B49E-236B01C800B4Q39443294-A8C5E8D2-CCFA-4E7E-A934-AEBB7762E943Q40066265-5234F933-97F3-41F8-BEDB-4485D1999DC8Q40303684-8C963EDE-76E5-4140-8586-2BE6395B72ABQ41472320-A291B352-8C2B-42BC-B0BA-5B75DB6301C6Q42684031-4EAA7109-83F1-4513-AEE3-ACC45E8ADC65Q46965482-1C898AB4-BA1E-4106-8F37-EE2673AE98EAQ46973951-EE09F4C7-4AF7-4256-91E5-B4C96D230504Q49225961-0F2AAB96-9581-45C0-AFD8-F08B57FCD6D8Q50295611-385A1808-8238-4C96-93F9-5AF7B16D9E7BQ51042807-7DD01988-8741-4ADA-8E7D-DBF493657592Q54982371-2109291F-B61C-404F-9AD9-2F0414856C58Q55012051-48843F2B-BBFE-4BFA-88B3-B25414BB37EDQ57817294-C9296550-472A-4D10-873E-7FD1BD3184FB
P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Why target PIM1 for cancer diagnosis and treatment?
@en
Why target PIM1 for cancer diagnosis and treatment?
@nl
type
label
Why target PIM1 for cancer diagnosis and treatment?
@en
Why target PIM1 for cancer diagnosis and treatment?
@nl
prefLabel
Why target PIM1 for cancer diagnosis and treatment?
@en
Why target PIM1 for cancer diagnosis and treatment?
@nl
P2093
P2860
P356
P1433
P1476
Why target PIM1 for cancer diagnosis and treatment?
@en
P2093
Nancy S Magnuson
Raymond Reeves
Zeping Wang
P2860
P304
P356
10.2217/FON.10.106
P407
P577
2010-09-01T00:00:00Z