about
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activitymTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptideProteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translationTumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinaseActivation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesRegulation of global and specific mRNA translation by the mTOR signaling pathwayThe expanding role of mTOR in cancer cell growth and proliferationNRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosisRSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activationThe coming of age of phosphoproteomics--from large data sets to inference of protein functionsQuantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.Activation of transcription factors NF-kappaB and NF-IL-6 by human immunodeficiency virus type 1 protein R (Vpr) induces interleukin-8 expressionCellular control of cortical actin nucleation.Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.Mutations in DOCK7 in individuals with epileptic encephalopathy and cortical blindnessEffect of the transient pharmacological inhibition of Mapk3/1 pathway on ovulation in mice.The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation.RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growthRegulation of karyopherin α1 and nuclear import by mammalian target of rapamycin.Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly.RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation.Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cellsInsulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism.A comprehensive map of the mTOR signaling network.Regulation and function of the RSK family of protein kinases.Regulation of mRNA translation by signaling pathwaysTranslational control by oncogenic signaling pathways.A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells.Casein kinase 1ε promotes cell proliferation by regulating mRNA translation.RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance.Defining the role of the RSK isoforms in cancer.ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1).mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.Mind the GAP: Wnt steps onto the mTORC1 train.The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling.K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK.Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt SignalingProteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Philippe P Roux
@nl
Philippe P Roux
@sl
Philippe P. Roux
@en
Philippe P. Roux
@es
type
label
Philippe P Roux
@nl
Philippe P Roux
@sl
Philippe P. Roux
@en
Philippe P. Roux
@es
prefLabel
Philippe P Roux
@nl
Philippe P Roux
@sl
Philippe P. Roux
@en
Philippe P. Roux
@es
P1053
J-3996-2012
P106
P1153
7103188887
P21
P2798
P31
P3829
P3835
philippe-p-roux
P4012
P496
0000-0002-5962-0250